Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences

Title: Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences

Volume: 14 Issue: 7

Author(s): Abdelaziz El Maatougui, Abel Crespo, Artur M.S. Silva and Alberto Coelho

Affiliation:

Keywords: Aza-Michael, Knoevenagel, polymer supported superbases, solution phase synthesis, TBD-Assisted, structural diversification, TBD, Alkylation, alkyl halides, methylene compounds, synthetic organic chemistry, high atom economy

Abstract: An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.

Cite this article as:

El Maatougui Abdelaziz, Crespo Abel, M.S. Silva Artur and Coelho Alberto, Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences, Combinatorial Chemistry & High Throughput Screening 2011; 14 (7) . https://dx.doi.org/10.2174/138620711796367229