Recent Developments in the Synthesis and Biological Activity of Muramylpeptides

Title: Recent Developments in the Synthesis and Biological Activity of Muramylpeptides

Volume: 18 Issue: 16

Author(s): K. Dzierzbicka, A. Wardowska and P. Trzonkowski

Affiliation:

Keywords: Muramyl dipeptide, MDP, MDP analogues, adjuvant, synthesis, cancer immunotherapy, innate immunity

Abstract: Derivatives of muramyl dipeptide (MDP) are considered as immunostimulants and adjuvants in the immunotherapy of cancer and infections. The interest in these compounds is mainly related to a high variety of their structure and biological properties. Here, we describe the synthesis and biological activity of several recently developed classes of MDP analogues. We also report potential of these analogues in the treatment of cancer and infectious diseases in experimental systems and cancer patients.

Cite this article as:

Dzierzbicka K., Wardowska A. and Trzonkowski P., Recent Developments in the Synthesis and Biological Activity of Muramylpeptides, Current Medicinal Chemistry 2011; 18 (16) . https://dx.doi.org/10.2174/092986711795843173