Modelling and Measuring Redox Cycling and Cytotoxicity of Quinones

Title: Modelling and Measuring Redox Cycling and Cytotoxicity of Quinones

Volume: 1 Issue: 4

Author(s): Louise Hughes, Jordana Wingate, Renate Griffith and R. John Aitken

Affiliation:

Keywords: Structure-activity relationships, quinone toxicity, alkylation, redox cycling

Abstract: The roles of alkylation and redox cycling in quinone toxicity were investigated. In general the more cytotoxic quinones produced the highest responses in an assay monitoring redox activity. No evidence of alkylation of high molecular weight protein thiols was detected. We conclude quinone toxicity is dominated by redox cycling.

Cite this article as:

Hughes Louise, Wingate Jordana, Griffith Renate and Aitken John R., Modelling and Measuring Redox Cycling and Cytotoxicity of Quinones, Drug Metabolism Letters 2007; 1 (4) . https://dx.doi.org/10.2174/187231207783221457