Mitochondria as Possible Pharmaceutical Targets for the Effects of Vitamin E and its Homologues in Oxidative Stress-Related Diseases

Hideyuki      J. Majima; Hiroko      P. Indo; Shigeaki      Suenaga; Hirofumi      Matsui; Hsiu-Chuan      Yen; Toshihiko      Ozawa

doi:10.2174/138161211796957490

Abstract

It is well known that vitamin E functions as an antioxidant, and it is expected to exert an antioxidant effect when taken as a supplement. However, a number of cohort studies have shown that vitamin E does not alleviate oxidative stress and could even worsen it. Recently, Wang et al. investigated whether vitamin E intake was associated with amyotrophic lateral sclerosis (ALS) based on data from 5 cohort studies with 1,055,546 participants, of which 805 of them had developed ALS. They concluded in this large pooled prospective study, in which long-term vitamin E supplementation was associated with lower ALS rates, and therefore, a possible protective effect of vitamin E deserves further consideration. Performing further large cohort studies may reveal similar findings for other oxidative stressrelated diseases. It is still controversial if antioxidants such as vitamin E provide a clinical therapeutic effect against oxidative stressrelated diseases. If effective, the dose at which they should be administered and the duration of supplement exposure should be of interest. Vitamin E reduces production of reactive oxygen species by mitochondria and elicits further reactions in cells. It should be noted that mitochondria are important targets for vitamin E and its homologues. Therefore, a proper usage of vitamin E in subjects under high oxidative stress, due to its individually targeting property, will arise its importance in healthy life.

Keywords: Antioxidant, Vitamin E, MnSOD, Mitochondria, ROS, Oxidative Disease, apoptosis, diabetes mellitus, glioma cells, submitochondrial particles