Abstract
In the present review we provide a summary of ATP-binding cassette (ABC) transporters in the central nervous system (CNS). Our review is focused on transporters of the ABC A, B, C, D, and G families that have been detected in the cells of the neurovascular unit/blood-brain barrier including brain capillary endothelial cells, pericytes, astrocytes, and neurons, as well as in other brain cells, such as microglia, oligodendrocytes, and choroid plexus epithelial cells. In this review, we provide an overview, organized by ABC family, of transporter expression, localization, and function. We summarize recent findings on ABC transporter regulation in the CNS and address the role of ABC transporters in CNS diseases including brain cancer, seizures/epilepsy, and Alzheimers disease. Finally, we discuss new therapeutic strategies focused on ABC transporters in CNS disease.
Keywords: ABCB1, ABCC, ABCG2, blood-brain barrier, breast cancer resistance protein, CNS, multidrug resistanceassociated protein, P-glycoprotein, ATP-binding cassette (ABC) transporters, transporter expression, seizures/epilepsy, Alzheimer's disease, neurovascular unit, ABC efflux
Current Pharmaceutical Biotechnology
Title: ABC Transporters in the CNS – An Inventory
Volume: 12 Issue: 4
Author(s): A. M.S. Hartz and B. Bauer
Affiliation:
Keywords: ABCB1, ABCC, ABCG2, blood-brain barrier, breast cancer resistance protein, CNS, multidrug resistanceassociated protein, P-glycoprotein, ATP-binding cassette (ABC) transporters, transporter expression, seizures/epilepsy, Alzheimer's disease, neurovascular unit, ABC efflux
Abstract: In the present review we provide a summary of ATP-binding cassette (ABC) transporters in the central nervous system (CNS). Our review is focused on transporters of the ABC A, B, C, D, and G families that have been detected in the cells of the neurovascular unit/blood-brain barrier including brain capillary endothelial cells, pericytes, astrocytes, and neurons, as well as in other brain cells, such as microglia, oligodendrocytes, and choroid plexus epithelial cells. In this review, we provide an overview, organized by ABC family, of transporter expression, localization, and function. We summarize recent findings on ABC transporter regulation in the CNS and address the role of ABC transporters in CNS diseases including brain cancer, seizures/epilepsy, and Alzheimers disease. Finally, we discuss new therapeutic strategies focused on ABC transporters in CNS disease.
Export Options
About this article
Cite this article as:
M.S. Hartz A. and Bauer B., ABC Transporters in the CNS – An Inventory, Current Pharmaceutical Biotechnology 2011; 12 (4) . https://dx.doi.org/10.2174/138920111795164020
DOI https://dx.doi.org/10.2174/138920111795164020 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
PET Radiopharmaceuticals for Personalized Medicine
Current Drug Targets Current Research on Opioid Receptor Function
Current Drug Targets Neurogenic Drugs and Compounds to Treat CNS Diseases and Disorders
Central Nervous System Agents in Medicinal Chemistry TrkB Receptor Agonist 7, 8 Dihydroxyflavone Triggers Profound Gender- Dependent Neuroprotection in Mice After Perinatal Hypoxia and Ischemia
CNS & Neurological Disorders - Drug Targets Studies on Target Genes of General Anesthetics
Current Drug Targets Molecular Recognisation of 3a, 4-Dihydro-3-H-Indeno [1, 2-C] Pyrazole-2- Carboxamide/Carbothioamide Anticonvulsant Analogues Towards GABA-Aminotransferase- An in Silico Approach
Central Nervous System Agents in Medicinal Chemistry GABAA Receptor Specific Pyrazolopyrimidines as Potential Imaging Agents: In Vivo Characteristics of a New 18F-labelled Indiplon Derivative
Current Radiopharmaceuticals Role of Grina/Nmdara1 in the Central Nervous System Diseases
Current Neuropharmacology Peptides Targeting Gap Junctional Structures
Current Pharmaceutical Design Coenzyme Q10 in Neuromuscular and Neurodegenerative Disorders
Current Drug Targets The Metabotropic Glutamate Receptors: Structure, Activation Mechanism and Pharmacology
Current Drug Targets - CNS & Neurological Disorders Importance of ABC Transporters in Drug Development
Current Pharmaceutical Design Antiepileptic Drugs for Preventing Seizures in Patients with Chronic Subdural Hematoma
Current Pharmaceutical Design Design of Lipophilic Prodrugs to Improve Drug Delivery and Efficacy
Current Drug Targets From Discovery to the Coming Generation of Histone Deacetylase Inhibitors
Current Medicinal Chemistry Adenosine, Ketogenic Diet and Epilepsy: The Emerging Therapeutic Relationship Between Metabolism and Brain Activity
Current Neuropharmacology Nitrogen, Oxygen or Sulfur Containing Heterocyclic Compounds as Analgesic Drugs Used as Modulators of the Nitroxidative Stress
Mini-Reviews in Medicinal Chemistry Desensitization of 5-HT-1A Somatodentritic Receptors in Tryptophan Treated and Co-treated Rats Induced by Methylphenidate
Current Clinical Pharmacology Targeting Ionotropic Glutamate Receptors in the Treatment of Epilepsy
Current Neuropharmacology Development of Radioligands for In Vivo Imaging of Type 1 Cannabinoid Receptors (CB1) in Human Brain
Current Pharmaceutical Design