The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury

Title:The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury

Volume: 22 Issue: 14

Author(s): Victor V. Uteshev, Olli Tenovuo and Nikhil Gaidhani

Affiliation:

Keywords: Trauma, brain, injury, cholinergic, nicotinic, acetylcholine, vagus, vagal, stimulation, inflammatory, immune.

Abstract: Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.

Cite this article as:

Uteshev V. Victor, Tenovuo Olli and Gaidhani Nikhil, The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury, Current Pharmaceutical Design 2016; 22 (14) . https://dx.doi.org/10.2174/1381612822666160127111630