Abstract
Vertebrates are armed with an array of pattern recognition receptors (PRRs) to sense viral pathogen associated molecular patterns (PAMPs). Upon activation, the PRRs trigger an interferon response which is central to host antiviral defence. Recent studies have demonstrated that the PRR surveillance system is well conserved in vertebrates during evolution. In fact, most classical PRRs characterised in mammals, such as Toll like receptors and the RIG-I-like receptors, have been identified in lower vertebrates. This review summarises recent progress in PRR recognition of viral PAMPs in teleost fish.
Keywords: Pattern recognition, Toll like receptors, RIG-I like receptor, protein kinase R, teleost fish
Current Pharmaceutical Design
Title: Antiviral Sensing in Teleost Fish
Volume: 16 Issue: 38
Author(s): Jun Zou, Steve Bird and Chris Secombes
Affiliation:
Keywords: Pattern recognition, Toll like receptors, RIG-I like receptor, protein kinase R, teleost fish
Abstract: Vertebrates are armed with an array of pattern recognition receptors (PRRs) to sense viral pathogen associated molecular patterns (PAMPs). Upon activation, the PRRs trigger an interferon response which is central to host antiviral defence. Recent studies have demonstrated that the PRR surveillance system is well conserved in vertebrates during evolution. In fact, most classical PRRs characterised in mammals, such as Toll like receptors and the RIG-I-like receptors, have been identified in lower vertebrates. This review summarises recent progress in PRR recognition of viral PAMPs in teleost fish.
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Cite this article as:
Zou Jun, Bird Steve and Secombes Chris, Antiviral Sensing in Teleost Fish, Current Pharmaceutical Design 2010; 16 (38) . https://dx.doi.org/10.2174/138161210794519093
DOI https://dx.doi.org/10.2174/138161210794519093 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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