Abstract
The concept according to which unique, rare and common sequences may define immunogenicity, immunopathogenicity and immunotolerance, respectively, is graphically illustrated using a melanoma-associatedantigen, Melan-A/Mart-1, as a model. The final picture is consolidated by experimentally validated data from the scientific literature and may represent a concrete prelude to effective immunotherapies exempt from collateral autoimmune reactions.
Keywords: Anti-cancer immunotherapy, autoimmunity, melan-A/Mart-1, immunogenicity, immunopathogenicity, immunotolerance, sequence similarity, the low-similarity theory.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Immunogenicity, Immunopathogenicity, and Immunotolerance in One Graph
Volume: 15 Issue: 10
Author(s): Darja Kanduc
Affiliation:
Keywords: Anti-cancer immunotherapy, autoimmunity, melan-A/Mart-1, immunogenicity, immunopathogenicity, immunotolerance, sequence similarity, the low-similarity theory.
Abstract: The concept according to which unique, rare and common sequences may define immunogenicity, immunopathogenicity and immunotolerance, respectively, is graphically illustrated using a melanoma-associatedantigen, Melan-A/Mart-1, as a model. The final picture is consolidated by experimentally validated data from the scientific literature and may represent a concrete prelude to effective immunotherapies exempt from collateral autoimmune reactions.
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Cite this article as:
Kanduc Darja, Immunogenicity, Immunopathogenicity, and Immunotolerance in One Graph, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (10) . https://dx.doi.org/10.2174/1871520615666150716105543
DOI https://dx.doi.org/10.2174/1871520615666150716105543 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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