Immunogenicity, Immunopathogenicity, and Immunotolerance in One Graph

Title:Immunogenicity, Immunopathogenicity, and Immunotolerance in One Graph

Volume: 15 Issue: 10

Author(s): Darja Kanduc

Affiliation:

Keywords: Anti-cancer immunotherapy, autoimmunity, melan-A/Mart-1, immunogenicity, immunopathogenicity, immunotolerance, sequence similarity, the low-similarity theory.

Abstract: The concept according to which unique, rare and common sequences may define immunogenicity, immunopathogenicity and immunotolerance, respectively, is graphically illustrated using a melanoma-associatedantigen, Melan-A/Mart-1, as a model. The final picture is consolidated by experimentally validated data from the scientific literature and may represent a concrete prelude to effective immunotherapies exempt from collateral autoimmune reactions.

Cite this article as:

Kanduc Darja, Immunogenicity, Immunopathogenicity, and Immunotolerance in One Graph, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (10) . https://dx.doi.org/10.2174/1871520615666150716105543