Abstract
Interleukin-25 (IL-25) plays a key role in the initiation and expansion of T helper (Th) 2 cell-mediated immune responses, thereby contributing to allergic diseases and host defense against helminthic parasites. More recent studies have however shown that IL-25 can also control the function of non-T cells, such as antigen presenting cells and endothelial cells, and reduces Th1/Th17-mediated pathologies. These new and exciting observations reveal a broader role for IL-25 than previously anticipated, and delineate various scenarios where therapeutic interventions around IL-25 activity can be imagined.
Keywords: IL-25, IBD, multiple sclerosis, diabetes, allergic diseases, Th cells, noxious agents, inflammatory bowel disease, TNF-, immunoglobulin E, inflammation, monoclonal antibodies, lymphoid tissue, immunity, nuocyte, Nippostrongylus brasiliensis, endotoxemia, preceding the development of overt disease, reduces the degree of CD4- and CD8-positive per-islet infi, RNA transcripts, atopic dermatitis, Crohn's disease, celiac disease, gluten-sensitive enteropathy
Current Molecular Medicine
Title: The Dual Role of Interleukin-25 in the Control of Immune-Mediated Pathologies
Volume: 11 Issue: 1
Author(s): R. Caruso, C. Stolfi, D. De Nitto, F. Pallone and G. Monteleone
Affiliation:
Keywords: IL-25, IBD, multiple sclerosis, diabetes, allergic diseases, Th cells, noxious agents, inflammatory bowel disease, TNF-, immunoglobulin E, inflammation, monoclonal antibodies, lymphoid tissue, immunity, nuocyte, Nippostrongylus brasiliensis, endotoxemia, preceding the development of overt disease, reduces the degree of CD4- and CD8-positive per-islet infi, RNA transcripts, atopic dermatitis, Crohn's disease, celiac disease, gluten-sensitive enteropathy
Abstract: Interleukin-25 (IL-25) plays a key role in the initiation and expansion of T helper (Th) 2 cell-mediated immune responses, thereby contributing to allergic diseases and host defense against helminthic parasites. More recent studies have however shown that IL-25 can also control the function of non-T cells, such as antigen presenting cells and endothelial cells, and reduces Th1/Th17-mediated pathologies. These new and exciting observations reveal a broader role for IL-25 than previously anticipated, and delineate various scenarios where therapeutic interventions around IL-25 activity can be imagined.
Export Options
About this article
Cite this article as:
Caruso R., Stolfi C., De Nitto D., Pallone F. and Monteleone G., The Dual Role of Interleukin-25 in the Control of Immune-Mediated Pathologies, Current Molecular Medicine 2011; 11 (1) . https://dx.doi.org/10.2174/156652411794474365
DOI https://dx.doi.org/10.2174/156652411794474365 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Exploiting Microglial Functions for the Treatment of Glioblastoma
Current Cancer Drug Targets Recent Advances on the Possible Neuroprotective Activities of Epstein- Barr Virus Oncogene BARF1 Protein in Chronic Inflammatory Disorders of Central Nervous System
Current Neuropharmacology Immunomodulatory and Anti-Viral Activities of Pertussis Toxin and of Its Non-Toxic Derivatives
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Evaluation of the Effects of a New Drug on Brain Leukocyte Infiltration in an Experimental Model of Autoimmune Encephalomyelitis
Letters in Drug Design & Discovery Targeting Histone Deacetylases for the Treatment of Immune, Endocrine & Metabolic Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Expression and Function of the Endocannabinoid System in Glial Cells
Current Pharmaceutical Design Inflammation in Parkinsons Diseases and Other Neurodegenerative Diseases: Cause and Therapeutic Implications
Current Pharmaceutical Design Mechanisms of the Penetration of Blood-Borne Substances into the Brain
Current Neuropharmacology Organoselenium Compounds as Potential Neuroprotective Therapeutic Agents
Current Organic Chemistry Editorial on the Occasion of the 20th Anniversary of Endocrine Metabolic Immune Disorders-Drug Targets Journal with a Kaleidoscopic Vision of Selected Publications
Endocrine, Metabolic & Immune Disorders - Drug Targets The Importance of NAD in Multiple Sclerosis
Current Pharmaceutical Design Apoptotic Cell Clearance and Autoimmune Disorder
Current Medicinal Chemistry Hormetic Potential of Sulforaphane (SFN) in Switching Cells’ Fate Towards Survival or Death
Mini-Reviews in Medicinal Chemistry The Ambivalent Role of Apoptosis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Current Pharmaceutical Design A Systematic Review of the Potential Herbal Sources of Future Drugs Effective in Oxidant-Related Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Pre-B Cell Colony Enhancing Factor/NAMPT/Visfatin in Inflammation and Obesity- Related Disorders
Current Pharmaceutical Design Venom Peptide Modulators of the Immune System
Inflammation & Allergy - Drug Targets (Discontinued) Nanostructures for Drug Delivery to the Brain
Current Medicinal Chemistry Fluorescent Substrates Useful as High Throughput Screening Tools for ADAM9
Combinatorial Chemistry & High Throughput Screening Nanomedicine and its Application in Treatment of Microglia-mediated Neuroinflammation
Current Medicinal Chemistry