Direct Colorimetric Biosensors from Polydiacetylenes

Title: Direct Colorimetric Biosensors from Polydiacetylenes

Volume: 15 Issue: 4

Author(s): Yong Chen, Xiaobo Nie, Xiaoyang Cui, Wenhe Wu, Jie Zhang, Chaowei Wen, Jimin Gao and Jinxin Lu

Affiliation:

Keywords: Colorimetric, Biosensors, Polydiacetylenes, fluorescent, electrochemical methods, Point-of-Care-Testing, receptor-analyte complex, conjugated polymers (CPs), poly-thiophenes, polyanilines, polypyrroles, polyphenylene, phenylene ethynylenes, polyacetylenes, polydiacety-lenes, Fourier transform infrared spectroscopy (FTIR), resonance Raman spectra, fluorescence polarization, atomic force microscopy, thermochromism, mechanical stress (mechanochromism), solvent (solvato-chromism), Atomic force microscopy (AFM), dimyristoylphosphatidylcholine (DMPC) vesicles, Chromism, colorimetric response, fluorescence resonance en-ergy transfer (FRET), Langmuir film, Influenza virus, H5N1 Hemagglutinin, E. coli [ATCC25922], E. coli K12, Cryptosporidium parvum, Human -fetoprotein, h-IgG, Microalbuminuria (MAU), Catecholamine, Cyclodextrins, Sialic acid, Dioctadecyl glyceryl ether--glucosides (DGG), D-mannopyranoside (MPDA), Cardiolipin, Anti-h-IgG antibody, Anti-MAU-antibody, Valinomycin, Monensin, Dimyristoylphosphatidylcholine(DMPC), Hexokinase, Tryptophan / Tyrosine, EDEA/EDA, Chemo/Biosensors, self-assembled monolayer (SAM), Cholera Toxin Biosensor

Abstract: Polydiacetylenes (PDAs) have gained much interest in recent years because of their distinctive chromatic transition property. The PDA molecules can be self-assembled into thin films or vesicles that could undergo blue-red transformations in response to different stimuli, like temperature, pH, and the presence of biological molecules. Due to this unique chromatic property, PDA materials have emerged as an attractive option for biosensing applications. Functionalized PDA has been used as a platform for detection of biological analytes, including viruses, microorganisms, and proteins. In this paper, we will review the formation of PDA films and vesicles, their optical properties, and their potential applications as biosensors.

Cite this article as:

Chen Yong, Nie Xiaobo, Cui Xiaoyang, Wu Wenhe, Zhang Jie, Wen Chaowei, Gao Jimin and Lu Jinxin, Direct Colorimetric Biosensors from Polydiacetylenes, Current Organic Chemistry 2011; 15 (4) . https://dx.doi.org/10.2174/138527211794474438