Abstract
5-fluorouracil (5-FU or f5U) is a pyrimidine analogue, and is used as an antineoplastic drug. Working with antineoplastic drugs constitutes a health hazard for the people who handle them, mainly because of their mutagenicity, teratogenicity and carcinogenicity. This is the reason, why the determination of antineoplastic drugs in wipe samples obtained from the hospital departments, where antineoplastic drugs are prepared or administered is growing in importance.
5-fluorouracil has some unusual pharmacological characteristics, which make it suitable for therapeutic drug monitoring. Thus, its determination in plasma and other body fluids or in urine is important, too. Like other drugs, 5-fluorouracil is also determined in formulations during quality control or stability studies.
Keywords: 5-fluorouracil, HPLC, Gas Chromatography, Capillary Electrophoresis, Thymidylate Synthase Inhibitor, Antineoplastic Drug, Mutagenicity, Teratogenicity, Carcinogenicity, Solar Keratoses, Basal Cell Carcinoma
Current Pharmaceutical Analysis
Title: 5-Fluorouracil – Characteristics and Analytical Determination
Volume: 7 Issue: 1
Author(s): Barbora Hansova, Stanislav Synek and Radka Opatrilova
Affiliation:
Keywords: 5-fluorouracil, HPLC, Gas Chromatography, Capillary Electrophoresis, Thymidylate Synthase Inhibitor, Antineoplastic Drug, Mutagenicity, Teratogenicity, Carcinogenicity, Solar Keratoses, Basal Cell Carcinoma
Abstract: 5-fluorouracil (5-FU or f5U) is a pyrimidine analogue, and is used as an antineoplastic drug. Working with antineoplastic drugs constitutes a health hazard for the people who handle them, mainly because of their mutagenicity, teratogenicity and carcinogenicity. This is the reason, why the determination of antineoplastic drugs in wipe samples obtained from the hospital departments, where antineoplastic drugs are prepared or administered is growing in importance.
5-fluorouracil has some unusual pharmacological characteristics, which make it suitable for therapeutic drug monitoring. Thus, its determination in plasma and other body fluids or in urine is important, too. Like other drugs, 5-fluorouracil is also determined in formulations during quality control or stability studies.
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Cite this article as:
Hansova Barbora, Synek Stanislav and Opatrilova Radka, 5-Fluorouracil – Characteristics and Analytical Determination, Current Pharmaceutical Analysis 2011; 7 (1) . https://dx.doi.org/10.2174/157341211794708767
DOI https://dx.doi.org/10.2174/157341211794708767 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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