Abstract
Integrins are adhesion receptors that connect cells to components of the extracellular matrix or to counter receptors on other cells. Besides mediating stable adhesion, these receptors are implicated in the deposition of extracellular matrices and they are crucial for cell migration. Integrin-mediated adhesion also modulates signal transduction cascades downstream of other receptors and thereby regulates cell survival, proliferation, and the expression of differentiation-related genes. In this review, an overview of the evidence for roles of integrins in tissue development and function is given and the contribution of changes in integrin expression to cancer is discussed.
Keywords: drosophila melanogaster, extracellular, matrix, arg-gly-asp
Current Pharmaceutical Design
Title: Integrins: Regulators of Tissue Function and Cancer Progression
Volume: 11 Issue: 7
Author(s): Erik H.J. Danen
Affiliation:
Keywords: drosophila melanogaster, extracellular, matrix, arg-gly-asp
Abstract: Integrins are adhesion receptors that connect cells to components of the extracellular matrix or to counter receptors on other cells. Besides mediating stable adhesion, these receptors are implicated in the deposition of extracellular matrices and they are crucial for cell migration. Integrin-mediated adhesion also modulates signal transduction cascades downstream of other receptors and thereby regulates cell survival, proliferation, and the expression of differentiation-related genes. In this review, an overview of the evidence for roles of integrins in tissue development and function is given and the contribution of changes in integrin expression to cancer is discussed.
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Cite this article as:
Danen H.J. Erik, Integrins: Regulators of Tissue Function and Cancer Progression, Current Pharmaceutical Design 2005; 11 (7) . https://dx.doi.org/10.2174/1381612053381756
DOI https://dx.doi.org/10.2174/1381612053381756 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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