Abstract
Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis. Beside their physiological expression patterns in Central Nervous System (CNS), it is conceivable that AQPs are also abnormally expressed in some pathological conditions interesting CNS (e.g. neurodegenerative diseases) in which preservation of brain homeostasis is at risk. The purpose of this review was to take in consideration those neurodegenerative diseases in whose pathogenetic processes it was possible to hypothesize some alterations in CNS AQPs expression or modulation leading to damages of brain water homeostasis.
Keywords: Aquaporins, CNS, Neurodegenerative Diseases
Current Neuropharmacology
Title: Aquaporins and Neurodegenerative Diseases
Volume: 8 Issue: 2
Author(s): Eleonora Foglio and Rodella Luigi Fabrizio
Affiliation:
Keywords: Aquaporins, CNS, Neurodegenerative Diseases
Abstract: Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis. Beside their physiological expression patterns in Central Nervous System (CNS), it is conceivable that AQPs are also abnormally expressed in some pathological conditions interesting CNS (e.g. neurodegenerative diseases) in which preservation of brain homeostasis is at risk. The purpose of this review was to take in consideration those neurodegenerative diseases in whose pathogenetic processes it was possible to hypothesize some alterations in CNS AQPs expression or modulation leading to damages of brain water homeostasis.
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Cite this article as:
Foglio Eleonora and Luigi Fabrizio Rodella, Aquaporins and Neurodegenerative Diseases, Current Neuropharmacology 2010; 8 (2) . https://dx.doi.org/10.2174/157015910791233150
DOI https://dx.doi.org/10.2174/157015910791233150 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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