Abstract
Optically active propargylic alcohols serve as an important building block in asymmetric synthesis. The customised synthesis of chiral ligands and transition metal activators as catalysts, to effect asymmetric alkynylation reactions, continue to feature in the literature. This review article focuses upon the use of Zn(OTf)2, in conjunction with 2-point chiral ligands, for effecting asymmetric alkynylation reactions to aldehydes.
Current Organic Chemistry
Title: Asymmetric Alkynylation Reactions of Aldehydes Using a Zn(OTf)2-Chiral Ligand-Base System
Volume: 13 Issue: 15
Author(s): Elizabeth Tyrrell
Affiliation:
Abstract: Optically active propargylic alcohols serve as an important building block in asymmetric synthesis. The customised synthesis of chiral ligands and transition metal activators as catalysts, to effect asymmetric alkynylation reactions, continue to feature in the literature. This review article focuses upon the use of Zn(OTf)2, in conjunction with 2-point chiral ligands, for effecting asymmetric alkynylation reactions to aldehydes.
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Tyrrell Elizabeth, Asymmetric Alkynylation Reactions of Aldehydes Using a Zn(OTf)2-Chiral Ligand-Base System, Current Organic Chemistry 2009; 13 (15) . https://dx.doi.org/10.2174/138527209789177716
DOI https://dx.doi.org/10.2174/138527209789177716 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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