Abstract
The present review contains a representative sampling from the last 10 years on the synthesis of biologically interesting compounds, prepared by the use of the 1,3-dipolar cycloaddition and Diels-Alder reactions, that have been eventually sequenced into cascade processes to assemble heterocyclic molecules. The important role of click chemistry for the synthesis of bio-inspired compounds have been also outlined.
Keywords: Cycloaddition Methodology, Diels-Alder reactions, heterocyclic molecules, synthesis
Current Organic Chemistry
Title: Cycloaddition Methodology: A Useful Entry Towards Biologically Active Heterocycles
Volume: 13 Issue: 5
Author(s): Ugo Chiacchio, Albert Padwa and Giovanni Romeo
Affiliation:
Keywords: Cycloaddition Methodology, Diels-Alder reactions, heterocyclic molecules, synthesis
Abstract: The present review contains a representative sampling from the last 10 years on the synthesis of biologically interesting compounds, prepared by the use of the 1,3-dipolar cycloaddition and Diels-Alder reactions, that have been eventually sequenced into cascade processes to assemble heterocyclic molecules. The important role of click chemistry for the synthesis of bio-inspired compounds have been also outlined.
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Cite this article as:
Chiacchio Ugo, Padwa Albert and Romeo Giovanni, Cycloaddition Methodology: A Useful Entry Towards Biologically Active Heterocycles, Current Organic Chemistry 2009; 13 (5) . https://dx.doi.org/10.2174/138527209787582268
DOI https://dx.doi.org/10.2174/138527209787582268 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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