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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Selection of Targets for Drug Development Against Protozoan Parasites

Author(s): Walter Filgueira de Azevedo Junior and Milena Botelho Pereira Soares

Volume 10, Issue 3, 2009

Page: [193 - 201] Pages: 9

DOI: 10.2174/138945009787581186

Price: $65

Abstract

Sequencing of parasite genomes opened the possibity to identify potential protein targets for drug development. Several protein targets have been found in the genome of Plasmodium falciparum, Trypanosoma cruzi, Trypanosoma brucei and Leishmania major. Bioinformatics analysis is an important tool for the identification of protein targets for drug development against parasitic diseases. In this review we comment about three protein targets, identified in parasite genomes, and discuss the main features that may guide future efforts for virtual screening initiatives.

Keywords: Virtual screening, parasites, molecular targets, drug design


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