Abstract
Stem cells build and maintain organisms. Accordingly, they are particularly well-protected from damage to DNA and other cellular components. This feature becomes a serious drawback when stem cells transform and develop cancer, because they resist to radiation and chemotherapy. Various mechanisms ensure protection of stem cells. In normal stem cells enhanced DNA repair is often one of them. Whether the same holds for cancer stem cells still is an open question.
Keywords: Stem cells, differentiation, DNA repair, CD133, cancer
Current Medicinal Chemistry
Title: DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System
Volume: 16 Issue: 7
Author(s): Guido Frosina
Affiliation:
Keywords: Stem cells, differentiation, DNA repair, CD133, cancer
Abstract: Stem cells build and maintain organisms. Accordingly, they are particularly well-protected from damage to DNA and other cellular components. This feature becomes a serious drawback when stem cells transform and develop cancer, because they resist to radiation and chemotherapy. Various mechanisms ensure protection of stem cells. In normal stem cells enhanced DNA repair is often one of them. Whether the same holds for cancer stem cells still is an open question.
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Cite this article as:
Frosina Guido, DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System, Current Medicinal Chemistry 2009; 16 (7) . https://dx.doi.org/10.2174/092986709787549253
DOI https://dx.doi.org/10.2174/092986709787549253 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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