PDGF-D Signaling: A Novel Target in Cancer Therapy

Title: PDGF-D Signaling: A Novel Target in Cancer Therapy

Volume: 10 Issue: 1

Author(s): Zhiwei Wang, Dejuan Kong, Yiwei Li and Fazlul H. Sarkar

Affiliation:

Keywords: PDGF-D, cancer, EMT, signaling, therapy, invasion, stem cells, nutrition

Abstract: Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-β. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.

Cite this article as:

Wang Zhiwei, Kong Dejuan, Li Yiwei and Sarkar H. Fazlul, PDGF-D Signaling: A Novel Target in Cancer Therapy, Current Drug Targets 2009; 10 (1) . https://dx.doi.org/10.2174/138945009787122914