Abstract
Dendritic cells are crucial in determining the functional outcome of allergen encounter in the lung. Antigen presentation by myeloid DCs leads to Th2 sensitization typical of allergic disease, whereas antigen presentation by plasmacytoid DCs serves to dampen inflammation. It is increasingly clear that DCs have an antigen presenting function beyond sensitisation. DCs therefore constitute a novel target for the development of anti-allergic therapy aimed at the origin of the inflammatory cascade. A careful study of DC biology and of the receptors expressed by lung DCs has provided a framework for the discovery of novel anti-allergic compounds.
Keywords: Dendritic Cells, Allergic Disease, immune system, Th2 cells, dampen inflammation, anti-allergic therapy, Drug Targets, Airway inflammation
Current Molecular Medicine
Title: Lung Dendritic Cells: Targets for Therapy in Allergic Disease
Volume: 8 Issue: 5
Author(s): Bart N. Lambrecht
Affiliation:
Keywords: Dendritic Cells, Allergic Disease, immune system, Th2 cells, dampen inflammation, anti-allergic therapy, Drug Targets, Airway inflammation
Abstract: Dendritic cells are crucial in determining the functional outcome of allergen encounter in the lung. Antigen presentation by myeloid DCs leads to Th2 sensitization typical of allergic disease, whereas antigen presentation by plasmacytoid DCs serves to dampen inflammation. It is increasingly clear that DCs have an antigen presenting function beyond sensitisation. DCs therefore constitute a novel target for the development of anti-allergic therapy aimed at the origin of the inflammatory cascade. A careful study of DC biology and of the receptors expressed by lung DCs has provided a framework for the discovery of novel anti-allergic compounds.
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Cite this article as:
Lambrecht N. Bart, Lung Dendritic Cells: Targets for Therapy in Allergic Disease, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785160916
DOI https://dx.doi.org/10.2174/156652408785160916 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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