Abstract
Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid- associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinated, cell- and context-specific manner. Each mediator serves regulatory and homeostatic functions in the onset and resolution of inflammation, immune responses, and tissue repair. The cloning of biosynthetic enzymes and G protein-coupled receptors for each of these mediators, the development of transgenic mice deficient in these molecules, and the availability of selective antagonists have permitted studies that have rapidly expanded our understanding of the scope of biologic functions for these mediators, with potential ramifications for the pathogenesis and treatment of human asthma. This review summarizes these findings and reviews the data from both mouse and human studies pertinent to the pathobiologic role of each mediator.
Keywords: Eicosanoids, leukotrienes, prostaglandins, lipoxins
Current Molecular Medicine
Title: Eicosanoids in Asthma, Allergic Inflammation, and Host Defense
Volume: 8 Issue: 5
Author(s): Joshua A. Boyce
Affiliation:
Keywords: Eicosanoids, leukotrienes, prostaglandins, lipoxins
Abstract: Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid- associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinated, cell- and context-specific manner. Each mediator serves regulatory and homeostatic functions in the onset and resolution of inflammation, immune responses, and tissue repair. The cloning of biosynthetic enzymes and G protein-coupled receptors for each of these mediators, the development of transgenic mice deficient in these molecules, and the availability of selective antagonists have permitted studies that have rapidly expanded our understanding of the scope of biologic functions for these mediators, with potential ramifications for the pathogenesis and treatment of human asthma. This review summarizes these findings and reviews the data from both mouse and human studies pertinent to the pathobiologic role of each mediator.
Export Options
About this article
Cite this article as:
Boyce A. Joshua, Eicosanoids in Asthma, Allergic Inflammation, and Host Defense, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785160989
DOI https://dx.doi.org/10.2174/156652408785160989 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Medicinal Mushroom: Phellinus Linteus
Current Medicinal Chemistry Editorial (Thematic Issue: Nutrition and Immunology in Diabetes, Cancer and Infectious Diseases)
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Targeting Trypanosoma cruzi Platelet-activating Factor Receptors: Scope for the Development of Novel Drugs to Treat Chagas Disease
Mini-Reviews in Medicinal Chemistry Targeting Airway Inflammation: Novel Therapies for the Treatment of Asthma
Current Medicinal Chemistry DNA Methylation Markers in Lung Cancer
Current Genomics Immunoproteomics for Serological Diagnosis of Hypersensitivity Pneumonitis Caused by Environmental Microorganisms
Current Protein & Peptide Science Nitric Oxide and Dietary Factors: Part I Nitric Oxide Synthesis and Action
Vascular Disease Prevention (Discontinued) Phytochemicals as Inhibitors of Candida Biofilm
Current Pharmaceutical Design Immune Function in Pregnant Women with Affective Disorders
Current Psychiatry Reviews Eosinophilopoiesis at the Cross-Roads of Research on Development, Immunity and Drug Discovery
Current Medicinal Chemistry Therapeutic Applications of Mesenchymal Stem Cells: A Comprehensive Review
Current Stem Cell Research & Therapy Small Molecules in Treatment of Sepsis
Current Drug Targets Trafficking Potentials of Unconventional T Cell Subsets
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents QSAR Study On 5-Lipoxygenase Inhibitors Based on Support Vector Machine
Medicinal Chemistry Advancements in Devices and Particle Engineering in Dry Powder Inhalation Technology
Current Topics in Medicinal Chemistry Capsaicin and Its Analogues: Structure-Activity Relationship Study
Current Medicinal Chemistry Paeonol, a Powerful Natural Product with Broad Biological Spectra by Inhibiting Inflammatory Pathway
Current Traditional Medicine Hypersensitivity Pneumonitis
Current Pediatric Reviews Targeting the Human Thioredoxin System by Diverse Strategies to Treat Cancer and Other Pathologies
Recent Patents on DNA & Gene Sequences Germinal and Somatic Trisomy 21 Mosaicism: How Common is it, What are the Implications for Individual Carriers and How Does it Come About?
Current Genomics