Abstract
Multi-arm constructs were synthesized and used in three different contexts, all involving pathogenic bacteria. Glycodendrimers containing either the GM1os ligand or its greatly simplified relative galactose, were found to be very strong cholera toxin inhibitors, especially at higher valencies. Related glycodendrimers containing the galabiose epitope were strong inhibitors of the adhesion of the bacterial pathogen Streptococcus suis. Finally, a synthetic vaccine against Bordetella pertussis was prepared by conjugating three different relevant peptidic epitopes to a single scaffold.
Anti-Infective Agents in Medicinal Chemistry
Title: Multivalent Presentation Strategies in Novel Inhibitors of Bacterial (Toxin) Adhesion and Synthetic Vaccines
Volume: 7 Issue: 3
Author(s): Roland J. Pieters and Rob M.J. Liskamp
Affiliation:
Abstract: Multi-arm constructs were synthesized and used in three different contexts, all involving pathogenic bacteria. Glycodendrimers containing either the GM1os ligand or its greatly simplified relative galactose, were found to be very strong cholera toxin inhibitors, especially at higher valencies. Related glycodendrimers containing the galabiose epitope were strong inhibitors of the adhesion of the bacterial pathogen Streptococcus suis. Finally, a synthetic vaccine against Bordetella pertussis was prepared by conjugating three different relevant peptidic epitopes to a single scaffold.
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Cite this article as:
Pieters J. Roland and Liskamp M.J. Rob, Multivalent Presentation Strategies in Novel Inhibitors of Bacterial (Toxin) Adhesion and Synthetic Vaccines, Anti-Infective Agents in Medicinal Chemistry 2008; 7 (3) . https://dx.doi.org/10.2174/187152108784911269
DOI https://dx.doi.org/10.2174/187152108784911269 |
Print ISSN 1871-5214 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6018 |
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