Abstract
In recent years, a number or review articles describing the utility of porphyrin-based compounds in photodynamic therapy have been published.1 Currently, efforts are also underway in various laboratories to increase the tumor-specificity by developing targetspecific photosensitizers. One of such attempts has been to synthesize a series of carbohydrate-porphyrin conjugates and investigate their ability to target carbohydrate- recognized proteins, which are known for their high expression in certain tumors. The present article is focused on the synthesis and biological significance of carbohydrate conjugated photosensitizers.
Keywords: Photodynamic therapy, Photofrin®, Porphyrin, Carbohydrate-Porphyrin Conjugates
Anti-Cancer Agents in Medicinal Chemistry
Title: Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)
Volume: 8 Issue: 3
Author(s): Xiang Zheng and Ravindra K. Pandey
Affiliation:
Keywords: Photodynamic therapy, Photofrin®, Porphyrin, Carbohydrate-Porphyrin Conjugates
Abstract: In recent years, a number or review articles describing the utility of porphyrin-based compounds in photodynamic therapy have been published.1 Currently, efforts are also underway in various laboratories to increase the tumor-specificity by developing targetspecific photosensitizers. One of such attempts has been to synthesize a series of carbohydrate-porphyrin conjugates and investigate their ability to target carbohydrate- recognized proteins, which are known for their high expression in certain tumors. The present article is focused on the synthesis and biological significance of carbohydrate conjugated photosensitizers.
Export Options
About this article
Cite this article as:
Zheng Xiang and Pandey K. Ravindra, Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT), Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (3) . https://dx.doi.org/10.2174/187152008783961897
DOI https://dx.doi.org/10.2174/187152008783961897 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sex Differences in Alcohol Use Disorder
Current Medicinal Chemistry Subject Index To Volume 1
Reviews on Recent Clinical Trials Bioactivity and Pharmacological Actions of Carbon Monoxide-Releasing Molecules
Current Pharmaceutical Design Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Patent Selections
Recent Patents on Biotechnology A Common Biological Mechanism in Cancer and Alzheimers Disease?
Current Alzheimer Research Cytotoxicity of a Vanadyl(IV) Complex with a Multidentate Oxygen Donor in Osteoblast Cell Lines in Culture
Medicinal Chemistry Editorial:Hot Topic: [Anti-Cancer Drugs(Executive Editor: Elke Bergmann-Leitner)]
Current Pharmaceutical Design Chronic Exposure to Low-Level Cadmium in Diabetes: Role of Oxidative Stress and Comparison with Polychlorinated Biphenyls
Current Drug Targets Computational Models and Methods for Drug Target Prediction and Drug Repositioning
Combinatorial Chemistry & High Throughput Screening Overview
Mini-Reviews in Medicinal Chemistry New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs
Current Neuropharmacology The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer
Clinical Cancer Drugs Recent Advance in the Pharmacology of Dihydropyrimidinone
Mini-Reviews in Medicinal Chemistry 3T Diffusion Weighted MR Imaging in Diagnosing Extrahepatic Cholangiocarcinoma
Current Medical Imaging The Role of Connexins in Carcinogenesis: Review of Current Knowledge
Current Signal Transduction Therapy Paracrine Provision of Lipids in the Immune System
Current Immunology Reviews (Discontinued) Review of Current Chemoinformatic Tools for Modeling Important Aspects of CYPsmediated Drug Metabolism. Integrating Metabolism Data with Other Biological Profiles to Enhance Drug Discovery
Current Drug Metabolism Resveratrol and Cancer: Chemoprevention, Apoptosis, and Chemoimmunosensitizing Activities
Current Medicinal Chemistry - Anti-Cancer Agents Physiological Proteins in Therapeutics: A Current Review on Interferons
Mini-Reviews in Medicinal Chemistry