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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Advance in the Pharmacology of Dihydropyrimidinone

Author(s): J.-P. Wan, Y. Pan

Volume 12, Issue 4, 2012

Page: [337 - 349] Pages: 13

DOI: 10.2174/138955712799829267

Price: $65

Abstract

Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and related studies of the scaffold, which lead to the discovery of many new biological functions of DHPMs. Recent pharmacological development on DHPMs-based molecules have been summarized in this review.

Keywords: Dihydropyrimidinone, pharmacology, enzyme/mitotic kinesin inhibitor, receptor antagonist, calcium channel blocker, adrenoceptor, Rho-associated, serine-threonine, polypeptides, kinesin


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