Orthopedic Implant Used as Drug Delivery System: Clinical Situation and State of the Research

Title: Orthopedic Implant Used as Drug Delivery System: Clinical Situation and State of the Research

Volume: 5 Issue: 1

Author(s): Dominique P. Pioletti, Olivier Gauthier, Vincent A. Stadelmann, Bruno Bujoli, Jerome Guicheux, Pierre-Yves Zambelli and Jean-Michel Bouler

Affiliation:

Keywords: Orthopedic implant, local delivery, drug, bone remodelling

Abstract: A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part, an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondly, a review of the clinical situation is developed for implants already used as drug delivery system. Experimental works performed for local delivery are reported. In particular, a description is given on the in vitro and in vivo studies where the implant is coated with different proteins or drugs. Finally, a conclusion is proposed on the next step in the development of orthopedic implant as drug delivery system mentioning also the industrial situation.

Cite this article as:

Pioletti P. Dominique, Gauthier Olivier, Stadelmann A. Vincent, Bujoli Bruno, Guicheux Jerome, Zambelli Pierre-Yves and Bouler Jean-Michel, Orthopedic Implant Used as Drug Delivery System: Clinical Situation and State of the Research, Current Drug Delivery 2008; 5 (1) . https://dx.doi.org/10.2174/156720108783331041