Abstract
The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/ reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological properties of all TRPV members in the light of various cellular functions of these channels and their significance in the systemic context of the mammalian organism.
Keywords: TRP channels, Vannilloid, TRPV, nociception, thermosensing, Ca2+ homeostasis, systemic diseases
Current Pharmaceutical Design
Title: Vanilloid Transient Receptor Potential Cation Channels: An Overview
Volume: 14 Issue: 1
Author(s): Bernd Nilius, Rudi Vennekens and Grzegorz Owsianik
Affiliation:
Keywords: TRP channels, Vannilloid, TRPV, nociception, thermosensing, Ca2+ homeostasis, systemic diseases
Abstract: The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/ reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological properties of all TRPV members in the light of various cellular functions of these channels and their significance in the systemic context of the mammalian organism.
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Cite this article as:
Nilius Bernd, Vennekens Rudi and Owsianik Grzegorz, Vanilloid Transient Receptor Potential Cation Channels: An Overview, Current Pharmaceutical Design 2008; 14 (1) . https://dx.doi.org/10.2174/138161208783330763
DOI https://dx.doi.org/10.2174/138161208783330763 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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