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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Vanilloid Transient Receptor Potential Cation Channels: An Overview

Author(s): Bernd Nilius, Rudi Vennekens and Grzegorz Owsianik

Volume 14, Issue 1, 2008

Page: [18 - 31] Pages: 14

DOI: 10.2174/138161208783330763

Price: $65

Abstract

The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/ reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological properties of all TRPV members in the light of various cellular functions of these channels and their significance in the systemic context of the mammalian organism.

Keywords: TRP channels, Vannilloid, TRPV, nociception, thermosensing, Ca2+ homeostasis, systemic diseases


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