Abstract
In the post-genomic era, microarray technology will have a major impact on our understanding of complex gene expression patterns and circuit function in the brain. Due to the phenotypic and transcript complexity of the brain, transcriptome profiling data is multifaceted, and is best interpreted in the context of the cellular diversity of the studied brain region. In the near future, massive microarray datasets will be placed into a biological context. To separate biologically significant transcriptome differences from experimental noise, verification of microarray data and anatomical localization of expression changes to neuronal subpopulations will continue to be an integral part of microarray experiments.
Keywords: Microarrays
Current Genomics
Title: Microarrays in Brain Research: Data Quality and Limitations
Volume: 3 Issue: 1
Author(s): Karoly Mirnics
Affiliation:
Keywords: Microarrays
Abstract: In the post-genomic era, microarray technology will have a major impact on our understanding of complex gene expression patterns and circuit function in the brain. Due to the phenotypic and transcript complexity of the brain, transcriptome profiling data is multifaceted, and is best interpreted in the context of the cellular diversity of the studied brain region. In the near future, massive microarray datasets will be placed into a biological context. To separate biologically significant transcriptome differences from experimental noise, verification of microarray data and anatomical localization of expression changes to neuronal subpopulations will continue to be an integral part of microarray experiments.
Export Options
About this article
Cite this article as:
Mirnics Karoly, Microarrays in Brain Research: Data Quality and Limitations, Current Genomics 2002; 3 (1) . https://dx.doi.org/10.2174/1389202023350598
DOI https://dx.doi.org/10.2174/1389202023350598 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Antimicrobial Peptides Expressed by Host Cells Upon Infection by Helicobacter pylori
Protein & Peptide Letters Integrins Modulate Cellular Fibrogenesis at Multiple Levels: Regulation of TGF-β Signaling
Endocrine, Metabolic & Immune Disorders - Drug Targets Antidepressants: Current Strategies and Future Opportunities
Current Pharmaceutical Design 5q- syndrome
Current Pharmaceutical Design Methotrexate: A Drug of the Future in Ulcerative Colitis?
Current Drug Targets Association Between Polycystic Ovary Syndrome and Metabolic Syndrome
Current Medicinal Chemistry Pharmacogenetics of Oxazaphosphorines and its Clinical Implications
Current Pharmacogenomics Apoptosis: A Key in Neurodegenerative Disorders
Current Neurovascular Research PEDF as an Emerging Therapeutic Candidate for Osteosarcoma
Current Cancer Drug Targets Antifungal Agents in Hematopoietic Stem Cell Transplantation
Current Pharmaceutical Design Infection and Anemia
Infectious Disorders - Drug Targets Intercellular Genomic (Chromosomal) Variations Resulting in Somatic Mosaicism: Mechanisms and Consequences
Current Genomics The Hypothalamic-Neurohypophyseal System: Current and Future Treatment of Vasopressin and Oxytocyn Related Disorders
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Using Endogenous Neural Stem Cells to Enhance Recovery from Ischemic Brain Injury
Current Neurovascular Research Vasculogenic and Angiogenic Pathways in Moyamoya Disease
Current Medicinal Chemistry Critical Parameters for Genome Editing Using Zinc Finger Nucleases
Mini-Reviews in Medicinal Chemistry Folate Nutrigenetics: A Convergence of Dietary Folate Metabolism, Folic Acid Supplementation, and Folate Antagonist Pharmacogenetics
Drug Metabolism Letters Patent Selections
Recent Patents on Biotechnology Progress Towards Recombinant Anti-Infective Antibodies
Recent Patents on Anti-Infective Drug Discovery Alterations in Glucose Metabolism in Alzheimer's Disease
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued)