Abstract
The decline in functional performance and restriction of adaptability represents the hallmark of skeletal muscle pathologies. The characteristic loss in muscle mass, coupled with a decrease in strength and force output, has been associated with a selective activation of apoptotic pathways and a general reduction in survival mechanisms. Aging and genetic diseases, such as muscular dystrophies, amyotrophic lateral sclerosis, cancer and AIDS, are characterized by alterations in metabolic and physiological parameters, progressive weakness in specific muscle groups, modulation in muscle-specific transcriptional mechanisms and persistent protein degradation. The inability to regenerate and repair the injured muscle is another serious complication in muscle pathologies. Tissue remodeling is therefore an important physiological process, which allows skeletal muscle to respond to environmental demands and to undergo adaptive changes in cytoarchitecture and protein composition, in response to a variety of stimuli. Alterations in extracellular agonists, receptors, protein kinases, intermediate molecules, transcription factors and tissue-specific gene expression compromise the functionality of skeletal muscle tissue, leading to muscle degeneration. Although considerable information has accumulated regarding the physiopathology of muscle diseases, the associated molecular mechanisms are still poorly understood. In this review, we will discuss the molecular basis of muscle atrophy, wasting and regeneration and the current gene and cell therapeutic approaches to attenuate atrophy and frailty associated with muscle diseases.
Keywords: myogenesis, muscle diseases, muscle wasting, proteolytic systems, muscle regeneration, therapeutic intervention, survival factors, stem cell
Current Genomics
Title: Attenuating Muscle Wasting: Cell and Gene Therapy Approaches
Volume: 4 Issue: 7
Author(s): A. Musaro and N. Rosenthal
Affiliation:
Keywords: myogenesis, muscle diseases, muscle wasting, proteolytic systems, muscle regeneration, therapeutic intervention, survival factors, stem cell
Abstract: The decline in functional performance and restriction of adaptability represents the hallmark of skeletal muscle pathologies. The characteristic loss in muscle mass, coupled with a decrease in strength and force output, has been associated with a selective activation of apoptotic pathways and a general reduction in survival mechanisms. Aging and genetic diseases, such as muscular dystrophies, amyotrophic lateral sclerosis, cancer and AIDS, are characterized by alterations in metabolic and physiological parameters, progressive weakness in specific muscle groups, modulation in muscle-specific transcriptional mechanisms and persistent protein degradation. The inability to regenerate and repair the injured muscle is another serious complication in muscle pathologies. Tissue remodeling is therefore an important physiological process, which allows skeletal muscle to respond to environmental demands and to undergo adaptive changes in cytoarchitecture and protein composition, in response to a variety of stimuli. Alterations in extracellular agonists, receptors, protein kinases, intermediate molecules, transcription factors and tissue-specific gene expression compromise the functionality of skeletal muscle tissue, leading to muscle degeneration. Although considerable information has accumulated regarding the physiopathology of muscle diseases, the associated molecular mechanisms are still poorly understood. In this review, we will discuss the molecular basis of muscle atrophy, wasting and regeneration and the current gene and cell therapeutic approaches to attenuate atrophy and frailty associated with muscle diseases.
Export Options
About this article
Cite this article as:
Musaro A. and Rosenthal N., Attenuating Muscle Wasting: Cell and Gene Therapy Approaches, Current Genomics 2003; 4 (7) . https://dx.doi.org/10.2174/1389202033490222
DOI https://dx.doi.org/10.2174/1389202033490222 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Patent Selections:
Recent Patents on Regenerative Medicine Cannabinoids and Parkinsons Disease
CNS & Neurological Disorders - Drug Targets Alzheimer´s Disease and Oxidative Stress: A Review
Current Medicinal Chemistry Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies
Mini-Reviews in Medicinal Chemistry P-gp Transporter and its Role in Neurodegenerative Diseases
Current Topics in Medicinal Chemistry The Prokaryotic FAD Synthetase Family: A Potential Drug Target
Current Pharmaceutical Design Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
Current Alzheimer Research Aquaporins and Neurodegenerative Diseases
Current Neuropharmacology Neuroprotective Role of Natural Polyphenols
Current Topics in Medicinal Chemistry Insights into the Mechanism of the Therapeutic Potential of Herbal Monoamine Oxidase Inhibitors in Neurological Diseases
Current Drug Targets Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets Pathophysiological Role of Mitochondrial Potassium Channels and their Modulation by Drugs
Current Medicinal Chemistry Instructions from the Vascular System - Directing Neural Stem Cell Fate in Health and Disease
Current Medicinal Chemistry Mesenchymal Stem Cells: Potential in Treatment of Neurodegenerative Diseases
Current Stem Cell Research & Therapy Structure – Function Relationships of Pre-Fibrillar Protein Assemblies in Alzheimers Disease and Related Disorders
Current Alzheimer Research Molecular Pathology in Neurodegenerative Diseases
Current Drug Targets Monoclonal Antibodies: A Target Therapy for Multiple Sclerosis
Inflammation & Allergy - Drug Targets (Discontinued) Transient Cerebral Ischemia Leads to TGF-β2 Expression in Golgi Apparatus Organelles
Current Neurovascular Research Use of Human Umbilical Cord Blood (HUCB) Cells to Repair the Damaged Brain
Current Neurovascular Research