Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

Title: Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

Volume: 12 Issue: 1

Author(s): Lidia Moreira Lima and Eliezer J. Barreiro

Affiliation:

Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-

Abstract: This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.

Cite this article as:

Lima Moreira Lidia and Barreiro J. Eliezer, Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design, Current Medicinal Chemistry 2005; 12 (1) . https://dx.doi.org/10.2174/0929867053363540