Of Man in Mouse: Modelling Human Cancer Genotype-Phenotype Correlations in Mice

Title: Of Man in Mouse: Modelling Human Cancer Genotype-Phenotype Correlations in Mice

Volume: 6 Issue: 2

Author(s): Maria Perez-Caro, Pedro A. Perez-Mancera, Felipe Voces and Isidro Sanchez-Garcia

Affiliation:

Keywords: mouse models, drug discovery, cancer process, cancer target cell, differentiation

Abstract: To date, many genetic changes have been described and reported in the cancer process. Since the first mutations were described, several attempts to establish genotype-phenotype correlations for these genetic alterations have been reported. Moreover, in vitro data have suggested effects of mutant proteins in proliferation. Genotype-phenotype correlations are not only important for predicting the clinical course of the disease and to allow tailor-made surveillance of individuals at risk, but also have implications for the elucidation of the molecular genetic mechanisms underlying genesis of cancer and the development of gene-based therapies. Here, we discuss genotype-phenotype correlation of cancer in mouse and man, and the functional aspects that may account for these observations important to both understand and treat the human disease process.

Cite this article as:

Perez-Caro Maria, Perez-Mancera A. Pedro, Voces Felipe and Sanchez-Garcia Isidro, Of Man in Mouse: Modelling Human Cancer Genotype-Phenotype Correlations in Mice, Current Genomics 2005; 6 (2) . https://dx.doi.org/10.2174/1389202053642276