Squalamine: A Polyvalent Drug of the Future?

Title: Squalamine: A Polyvalent Drug of the Future?

Volume: 5 Issue: 4

Author(s): Jean Michel Brunel, Chanaz Salmi, Celine Loncle, Nicolas Vidal and Yves Letourneux

Affiliation:

Keywords: squalamine, aminosterol, cancer, age-related macular degeneration (amd), appetite suppression, weight reduction

Abstract: The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?

Cite this article as:

Brunel Michel Jean, Salmi Chanaz, Loncle Celine, Vidal Nicolas and Letourneux Yves, Squalamine: A Polyvalent Drug of the Future?, Current Cancer Drug Targets 2005; 5 (4) . https://dx.doi.org/10.2174/1568009054064642