Abstract
Natriuretic peptides (NPs) are endogenous low molecular weight peptides known for their hypotensive activities. Due to their ability to induce both natriuresis (Na+ secretion) and diuresis, in fact, these peptides can profoundly decrease the body haemodynamic load, an effect which represents a main goal for all therapies aiming at improving the health of those subjects affected by different forms of heart and kidney failure. Over the years, many evidences have been provided for the involvement of NPs in the control of different cardiovascular parameters both in physiological and pathological conditions. This has led many researchers to test the possible therapeutic effects of different NPs and the pharmacological industries to develop exogenous NPs forms with a higher activity. This review aims then at summarizing the current knowledge about the therapeutic and clinical applications of NPs, also considering “atypical” NPs and the problems yet to be solved.
Keywords: C-type Natriuretic Peptide, NPPB gene, congestive heart failure, neutral endopeptidase 24.11, Dendroaspis Natriuretic Peptide
Current Pharmaceutical Analysis
Title: Pharmacological and Clinical Applications of Natriuretic Peptides: Accepted Knowledges or Changing Views?
Volume: 3 Issue: 3
Author(s): Izzi Valerio, Chiurchiu Valerio and Baldini P. Morena
Affiliation:
Keywords: C-type Natriuretic Peptide, NPPB gene, congestive heart failure, neutral endopeptidase 24.11, Dendroaspis Natriuretic Peptide
Abstract: Natriuretic peptides (NPs) are endogenous low molecular weight peptides known for their hypotensive activities. Due to their ability to induce both natriuresis (Na+ secretion) and diuresis, in fact, these peptides can profoundly decrease the body haemodynamic load, an effect which represents a main goal for all therapies aiming at improving the health of those subjects affected by different forms of heart and kidney failure. Over the years, many evidences have been provided for the involvement of NPs in the control of different cardiovascular parameters both in physiological and pathological conditions. This has led many researchers to test the possible therapeutic effects of different NPs and the pharmacological industries to develop exogenous NPs forms with a higher activity. This review aims then at summarizing the current knowledge about the therapeutic and clinical applications of NPs, also considering “atypical” NPs and the problems yet to be solved.
Export Options
About this article
Cite this article as:
Izzi Valerio , Chiurchiu Valerio and Baldini P. Morena , Pharmacological and Clinical Applications of Natriuretic Peptides: Accepted Knowledges or Changing Views?, Current Pharmaceutical Analysis 2007; 3 (3) . https://dx.doi.org/10.2174/157341207781369376
DOI https://dx.doi.org/10.2174/157341207781369376 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Iron Deficiency and Overload in the Pathogenesis of Diabetes and Diabetic Complications
Current Medicinal Chemistry Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management
Current Pediatric Reviews Antiplatelet Therapy in Children: Why So Different from Adults’?
Current Pharmaceutical Design Radiocontrast Nephropathy: Progress not Prevention
Current Cardiology Reviews Hypersensitivity Reactions to Last Generation Chimeric, Umanized and Human Recombinant Monoclonal Antibodies for Therapeutic Use
Current Pharmaceutical Design History and Global Status of the New Coronavirus Covid-2019 and Aspects of Previous Infections of SARS-CoV and MERS-CoV: A Systematic Review
Coronaviruses Effects of Statins on Blood Pressure: A Review of the Experimental and Clinical Evidence.
Current Vascular Pharmacology Peptides as Carrier for Tumor Diagnosis and Treatment
Current Medicinal Chemistry - Anti-Cancer Agents In Vitro Human Hepatocyte-Based Experimental Systems for the Evaluation of Human Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity in Drug Development
Current Topics in Medicinal Chemistry Biologics and the Cardiovascular System: A Double-Edged Sword
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Aripiprazole: An FDA Approved Bioactive Compound to Treat Schizophrenia- A Mini Review
Current Drug Discovery Technologies HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles
Current Cancer Drug Targets Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Catestatin: A Master Regulator of Cardiovascular Functions
Current Medicinal Chemistry Tolvaptan: A New Therapeutic Agent
Reviews on Recent Clinical Trials Endothelin-1 and Human Platelets
Current Vascular Pharmacology Sympathetic Overactivity in Hypertension and Cardiovascular Disease
Current Vascular Pharmacology Alogliptin; A Review of a New Dipeptidyl Peptidase-4 (DPP-4) Inhibitor for the Treatment of Type 2 Diabetes Mellitus
Cardiovascular & Hematological Disorders-Drug Targets Cell Cycle Inhibition in Malignant Lymphoma: Disease Control by Attacking the Cellular Proliferation Machinery
Current Drug Targets Endocannabinoids and Their Receptors: Physiology, Pathology and Pharmacology
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)