Abstract
1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.
Keywords: electron-withdrawing groups, 4-unsubstituted pyridine, calcium antagonists, vasodilation, hypertension
Current Organic Chemistry
Title: Chemical and Pharmacological Significance of 1,4-Dihydropyridines
Volume: 11 Issue: 10
Author(s): Ghanta Mahesh Reddy, Mehendra Shiradkar and Akula Kalyan Chakravarthy
Affiliation:
Keywords: electron-withdrawing groups, 4-unsubstituted pyridine, calcium antagonists, vasodilation, hypertension
Abstract: 1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.
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Cite this article as:
Ghanta Mahesh Reddy , Mehendra Shiradkar and Akula Kalyan Chakravarthy , Chemical and Pharmacological Significance of 1,4-Dihydropyridines, Current Organic Chemistry 2007; 11 (10) . https://dx.doi.org/10.2174/138527207781024058
DOI https://dx.doi.org/10.2174/138527207781024058 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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