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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Chemical and Pharmacological Significance of 1,4-Dihydropyridines

Author(s): Ghanta Mahesh Reddy, Mehendra Shiradkar and Akula Kalyan Chakravarthy

Volume 11, Issue 10, 2007

Page: [847 - 852] Pages: 6

DOI: 10.2174/138527207781024058

Price: $65

Abstract

1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.

Keywords: electron-withdrawing groups, 4-unsubstituted pyridine, calcium antagonists, vasodilation, hypertension


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