Abstract
Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQs involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor.
Keywords: Nociceptin/orphanin FQ, N/OFQ, nociceptin/orphanin FQ peptide (NOP) receptor, opioid receptor like-1 (ORL-1), opioid receptor-4 (OP4), kappa-type 3 opioid receptor (KOR-3), rat opioid receptor-C (ROR-C), obesity, food intake
Mini-Reviews in Medicinal Chemistry
Title: Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity
Volume: 8 Issue: 8
Author(s): Magdalena J. Przydzial and Lora K. Heisler
Affiliation:
Keywords: Nociceptin/orphanin FQ, N/OFQ, nociceptin/orphanin FQ peptide (NOP) receptor, opioid receptor like-1 (ORL-1), opioid receptor-4 (OP4), kappa-type 3 opioid receptor (KOR-3), rat opioid receptor-C (ROR-C), obesity, food intake
Abstract: Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQs involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor.
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Przydzial J. Magdalena and Heisler K. Lora, Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity, Mini-Reviews in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/138955708784912139
DOI https://dx.doi.org/10.2174/138955708784912139 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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