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Current Analytical Chemistry

Editor-in-Chief

ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Calixarene HPLC Phases - Applications

Author(s): Rudiger Meyer and Thomas Jira

Volume 3, Issue 2, 2007

Page: [161 - 170] Pages: 10

DOI: 10.2174/157341107780361736

Price: $65

Abstract

Calixarenes, following cyclodextrines and crown ethers, are the third generation of supramolecules used in HPLC as stationary phases. They consist of phenol units linked via methylene bridges and can also form inclusion complexes like the other host supramolecules. The resulting interactions influence the retention factors and improve the selectivity of the solutes. Additionally, modification of the calixarenes, for instance by varying the ring size, substitutents, conformations and pKa values, enable a more enhanced interaction spectrum and can improve the specificity for guest molecules. The application of calixarenes in chromatography also includes medical and environmental applications, preparative chemistry as well as the rapidly developing area of supramolecular chemistry. Taking the possibilities and the growing interests of calixarenes into account, the aim of the review is to summarise the application possibilities and interactions of calixarenes as stationary phase in HPLC.

Keywords: Calixarene-bonded stationary phases, HPLC

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