Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitors of Protein Kinases

Title: Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitors of Protein Kinases

Volume: 6 Issue: 6

Author(s): Alex Kiselyov, Konstantin V. Balakin, Sergey E. Tkachenko and Nikolay P. Savchuk

Affiliation:

Keywords: Protein kinases, Tyrosine kinases, Serine/threonine kinases, Non-ATP competitive inhibitor, Allosteric binding, Library design

Abstract: The majority of marketed and late stage development kinase inhibitors are reported to be ATPcompetitive. As a result, many promising drug candidates display non-specific activity that results in undesired physiological effects. There is growing interest towards non-ATP competitive kinase inhibitors, as they are expected to yield highly specific and efficacious molecules devoid of non-mechanistic toxicity. Recent developments in this area are summarized in our review.

Cite this article as:

Kiselyov Alex, Balakin V. Konstantin, Tkachenko E. Sergey and Savchuk P. Nikolay, Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitors of Protein Kinases, Mini-Reviews in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/138955706777435698