Abstract
Reactive oxygen species (ROS) are proposed to induce cardiovascular diseases, such as atherosclerosis and hypertension, through several mechanisms. One such mechanism involves ROS acting as intracellular second messengers, which lead to induction of unique signal transductions. Angiotensin II (AngII), a potent cardiovascular pathogen, stimulates ROS production through vascular NADPH oxidases. The ROS production induced by AngII activates downstream ROS-sensitive kinases that are critical in mediating cardiovascular remodeling. Recent advances in gene transfer/knockout techniques have lead to numerous in vitro and in vivo studies that identify the potential components and mechanisms of ROS signal transduction by AngII which promote cardiovascular remodeling. In this review, we will focus our discussion on the signal transduction research elucidating ROS production and function induced by AngII using currently available molecular biotechnologies.
Keywords: protein kinase C (PKC), NADPH oxidase, p47phox knockout mice, ADAM family, Proteomic Approaches
Current Pharmaceutical Biotechnology
Title: Current Understanding of the Mechanism and Role of ROS in Angiotensin II Signal Transduction
Volume: 7 Issue: 2
Author(s): Hiroyuki Suzuki, Gerald D. Frank, Hirotoshi Utsunomiya, Sadaharu Higuchi and Satoru Eguchi
Affiliation:
Keywords: protein kinase C (PKC), NADPH oxidase, p47phox knockout mice, ADAM family, Proteomic Approaches
Abstract: Reactive oxygen species (ROS) are proposed to induce cardiovascular diseases, such as atherosclerosis and hypertension, through several mechanisms. One such mechanism involves ROS acting as intracellular second messengers, which lead to induction of unique signal transductions. Angiotensin II (AngII), a potent cardiovascular pathogen, stimulates ROS production through vascular NADPH oxidases. The ROS production induced by AngII activates downstream ROS-sensitive kinases that are critical in mediating cardiovascular remodeling. Recent advances in gene transfer/knockout techniques have lead to numerous in vitro and in vivo studies that identify the potential components and mechanisms of ROS signal transduction by AngII which promote cardiovascular remodeling. In this review, we will focus our discussion on the signal transduction research elucidating ROS production and function induced by AngII using currently available molecular biotechnologies.
Export Options
About this article
Cite this article as:
Suzuki Hiroyuki, Frank D. Gerald, Utsunomiya Hirotoshi, Higuchi Sadaharu and Eguchi Satoru, Current Understanding of the Mechanism and Role of ROS in Angiotensin II Signal Transduction, Current Pharmaceutical Biotechnology 2006; 7 (2) . https://dx.doi.org/10.2174/138920106776597667
DOI https://dx.doi.org/10.2174/138920106776597667 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial (New Wave from Immunology, Endocrine & Metabolic Agents in Medicinal Chemistr )
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Editorial [Hot Topic:Modifying Cardiovascular Risk Factors: Newer Insights and Preventive Measures (Executive Editor: Aurelio Leone)]
Current Pharmaceutical Design Heme Oxygenase-1: A Potential Antihypertensive Target?
Current Hypertension Reviews “Epileptic Encephalopathy” of Infancy and Childhood: Electro-Clinical Pictures and Recent Understandings
Current Neuropharmacology Therapeutic Interventions for Advanced Glycation-End Products and its Receptor- Mediated Cardiovascular Disease
Current Pharmaceutical Design Impact of Periconceptional Undernutrition on the Development of the Hypothalamo-Pituitary-Adrenal Axis: Does the Timing of Parturition Start at Conception?
Current Drug Targets Regulation of Body Fluid and Salt Homeostasis - from Observations in Space to New Concepts on Earth
Current Pharmaceutical Biotechnology Meet Our Editorial Board Member
Current Drug Discovery Technologies Soy Isoflavones and Cardiovascular Health: An Update
Current Nutrition & Food Science Tailored Angiogenesis Inhibition in Cancer Therapy: Respecting the Heart to Improve the Net Outcome
Current Signal Transduction Therapy Anti-Diabetic
Current Bioactive Compounds Liver-Directed Regional Therapy in the Multi-Disciplinary Management of Hepatocellular Cancer
Current Cancer Therapy Reviews Theory and Application of Microdialysis in Pharmacokinetic Studies
Current Drug Metabolism Erythropoietin in Stroke Therapy: Friend or Foe
Current Medicinal Chemistry Design, Synthesis, and Bioactivity of Pyrazole Acid Derivatives as Endothelin Receptor Antagonists
Medicinal Chemistry Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression: Inferences from Observational Cohort Studies and Interventional Trials
Current Pharmaceutical Design Adrenomedullins: Therapeutic Potential in Cardiovascular Disease
Current Hypertension Reviews Anesthetic Pharmacology and Perioperative Considerations for Heart Transplantation
Current Clinical Pharmacology A Role for Endothelin-1 in Peripheral Vascular Disease
Current Vascular Pharmacology Novel 4-Oxothienopyrimidinyl Propanoic Acid Derivatives as AMPActivated Protein Kinase (AMPK) Activators
Letters in Drug Design & Discovery