Novel 4-Oxothienopyrimidinyl Propanoic Acid Derivatives as AMPActivated Protein Kinase (AMPK) Activators

Title:Novel 4-Oxothienopyrimidinyl Propanoic Acid Derivatives as AMPActivated Protein Kinase (AMPK) Activators

Volume: 11 Issue: 6

Author(s): Chandrasekhar Abbineni, Saibal Kumar Das, Rashmi Talwar, Parimal Misra, Vijay Potluri, Menon C. A. Vinu, Thammera Ranjith Kumar, S. Sridhar, M. Roshaiah, Pradip K. Sasmal, P. Narasimha Rao, Khaji Abdul Rawoof, Poondla. Neelima, Nutakki Ravi Kumar, Megha Bhattacharya, M. Munikumar, P. Tirumala Rao and Mahaboobi Jaleel

Affiliation:

Keywords: AMP-activated protein kinase (AMPK), AMPK activators, Thienopyrimidinone derivatives, Type-2 diabetes mellitus, db/db mice model.

Abstract: Adenosine 5’-monophosphate (AMP) activated protein kinase (AMPK) is a highly conserved sensor of cellular energy. AMPK has been recognized as a key regulator of mammalian metabolic function and has emerged as an attractive target for the treatment of metabolic disorders, including obesity and type 2 diabetes. The synthesis and biological evaluation of novel 3-(4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)propanoic acid derivatives as AMPK activators are described. The in vivo proof of principle for plasma glucose lowering effect is exemplified with a lead compound from this series.

Cite this article as:

Abbineni Chandrasekhar, Das Kumar Saibal, Talwar Rashmi, Misra Parimal, Potluri Vijay, Vinu C. A. Menon, Kumar Ranjith Thammera, Sridhar S., Roshaiah M., Sasmal K. Pradip, Rao Narasimha P., Rawoof Abdul Khaji, Neelima Poondla., Kumar Ravi Nutakki, Bhattacharya Megha, Munikumar M., Rao Tirumala P. and Jaleel Mahaboobi, Novel 4-Oxothienopyrimidinyl Propanoic Acid Derivatives as AMPActivated Protein Kinase (AMPK) Activators, Letters in Drug Design & Discovery 2014; 11 (6) . https://dx.doi.org/10.2174/1570180811666140122003044

DOI https://dx.doi.org/10.2174/1570180811666140122003044	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X