Abstract
Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.
Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression
Current Molecular Medicine
Title: The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins
Volume: 6 Issue: 1
Author(s): Scott A. Oakes, Stephen S. Lin and Michael C. Bassik
Affiliation:
Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression
Abstract: Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.
Export Options
About this article
Cite this article as:
Oakes A. Scott, Lin S. Stephen and Bassik C. Michael, The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins, Current Molecular Medicine 2006; 6 (1) . https://dx.doi.org/10.2174/156652406775574587
DOI https://dx.doi.org/10.2174/156652406775574587 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Using Non-Pharmacological Approaches for CJD Patient and Family Support as Provided by the CJD Foundation and CJD Insight
CNS & Neurological Disorders - Drug Targets Methotrexate-Induced Pneumonitis: Heterogeneity of Bronchoalveolar Lavage and Differences between Cancer and Rheumatoid Arthritis
Inflammation & Allergy - Drug Targets (Discontinued) Genetic Variation in SLCO2B1 is Associated with Serum Levels of Testosterone and its Metabolites Prior to and Two Days after Testosterone Administration
Current Pharmacogenomics and Personalized Medicine Abnormal Striatal Dopamine Transmission in Schizophrenia
Current Medicinal Chemistry Alzheimers Disease: Interactions Between Cholinergic Functions and β- amyloid
Current Alzheimer Research The Endocannabinoid System in Ageing: A New Target for Drug Development
Current Drug Targets Quantitative Relationship Between Rifampicin Exposure and Induction of CYP3a11 in SXR Humanized Mice: Extrapolation to Human CYP3A4 Induction Potential
Drug Metabolism Letters Epidermolysis Bullosa: The Pediatricians Role
Current Pediatric Reviews Reduction of Oxidative/Nitrosative Stress in Brain and its Involvement in the Neuroprotective Effect of n-3 PUFA in Alzheimer’s Disease
Current Alzheimer Research Cellular Receptors of Extracellular Matrix Molecules
Current Pharmaceutical Design Sepsis-induced Cardiomyopathy
Current Cardiology Reviews Disruption of Circadian Rhythms in Critical Illness - A Role of Hyperoxia-Induced Lung Injury
Current Pharmaceutical Design Dual Inhibition of DPP-4 and Cholinesterase Enzymes by the Phytoconstituents of the Ethanolic Extract of Prosopis cineraria Pods: Therapeutic Implications for the Treatment of Diabetes-associated Neurological Impairments
Current Alzheimer Research Microvascular Alterations in Hypertension and Vascular Aging
Current Hypertension Reviews Synergistic Effect of Curcumin: A Review
Current Bioactive Compounds The Retinal Pigment Epithelium in Health and Disease
Current Molecular Medicine Microwave Accelerated Synthesis of PET Image Contrast Agents for AD Research
Current Alzheimer Research Vitamins and Cognition: A Nutrigenomics Perspective
Current Nutrition & Food Science Comparison of Cytocidal Activities of L-DOPA and Dopamine in <i>S. cerevisiae</i> and <i>C. glabrata</i>
Current Bioactive Compounds Inflammatory Responses in Brain Ischemia
Current Medicinal Chemistry