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Review Article

Exploring Current Role of Nanotechnology Used in Food Processing Industry to Control Food Additives and their Biochemical Mechanisms

Author(s): Sudatta Dey, Asmita Samadder* and Sisir Nandi*

Volume 23, Issue 5, 2022

Published on: 26 January, 2022

Page: [513 - 539] Pages: 27

DOI: 10.2174/1389450123666211216150355

Price: $65

Abstract

Background: With the advent of food additives centuries ago, the human race has found ways to improve and maintain the safety of utility, augment the taste, color, texture, nutritional value, and appearance of the food. Since the 19th century, when the science behind food spoilage was discerned, food additives in food preservation have been increasing worldwide and at a fast pace to get along with modern lifestyles. Although food additives are thought to be used to benefit the food market, some of them are found to be associated with several health issues at an alarming rate. Studies are still going on regarding the mechanisms by which food additives affect public health. Therefore, an attempt has been made to find out the remedies by exploiting technologies that may convey new properties of food additives that can only enhance the quality of food without having any systemic side effects. Thus, this review focuses on the applications of nanotechnology in the production of nano-food additives and evaluates its success regarding reduction in the health-related hazards by collaterally maintaining the food nutrient value.

Methodology: A thorough literature study was performed using scientific databases, like PubMed, Science Direct, Scopus, and Web of Science, for determining the design of the study, and each article was checked for citation and referred to formulate the present review article.

Conclusion: Nanotechnology can be applied in the food processing industry to control the unregulated use of food additives and intervene in the biochemical mechanisms at a cellular and physiological level for ensuring the safety of food products. The prospective of nano-additive of chemical origin could be useful to reduce risks of hazards related to human health that are caused majorly due to the invasion of food contaminants (either intentional or non-intentional) into food, though this area still needs scientific validation. Therefore, this review provides comprehensive knowledge on different facets of food contaminants and also serves as a platform of ideas for encountering health risk problems about the design of improved versions of nano-additives.

Keywords: Nanotechnology, food additives, Acceptable Daily Intake (ADI), molecular targets, safety measurements, human health hazards.

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[1]
Dar HY, Chaturvedi S, Srivastava K, et al. Immunomodulatory effects of food additives. Int J Immunother Cancer Res 2017; 3(1): 019-31.
[2]
Carocho M, Barreiro MF, Morales P, Ferreira ICFR. Adding molecules to food, pros and cons: a review on synthetic and natural food additives. Compr Rev Food Sci Food Saf 2014; 13(4): 377-99.
[http://dx.doi.org/10.1111/1541-4337.12065] [PMID: 33412697]
[3]
International Food Information Council (IFIC) and U.S. Food and Drug Administration (FDA). Overview of food ingredients, additives & colors. 2010. Reference: Available from: https://www.fda.gov/food/food-ingredients-packaging/overview-food-ingredients-additives-colors#qayellow5 (Accessed November, 2004; Revised April, 2010).
[4]
Guidance for the preparation of dossiers for sensory additives. EFSA J 2012; 10(1): 2534.
[http://dx.doi.org/10.2903/j.efsa.2012.2534]
[5]
Giaccone V, Cammilleri G, Di Stefano V, et al. First report on the presence of Alloxan in bleached flour by LC-MS/MS method. J Cereal Sci 2017; 77: 120-5.
[http://dx.doi.org/10.1016/j.jcs.2017.06.015]
[6]
Hart JR. EDTA-type chelating agents in everyday consumer products: Some food, cleaning, and photographic applications. J Chem Educ 1985; 62(1): 75.
[http://dx.doi.org/10.1021/ed062p75]
[7]
Nauta T. Chelating agents. In: Smith J, Ed. Food Additive User’s Handbook. Boston, MA: Springer 1991; pp. 273-9.
[8]
Soleas GJ, Goldberg DM. Potential role of clarifying agents in the removal of pesticide residues during wine production and their effects upon wine quality. J Wine Res 2010; 11(1): 19-34.
[http://dx.doi.org/10.1080/713684210]
[9]
Li ZX, Wang GM, Liang Q. Preparation and properties of the novel adsorbent agent for juices clarification. Adv Mat Res 2013; (791-793): 248-51.
[http://dx.doi.org/10.4028/www.scientific.net/AMR.791-793.248]
[10]
Sen K, Cabaroglu T, Yilmaz H. The influence of fining agents on the removal of some pesticides from white wine of Vitis vinifera L. cv. Emir. Food Chem Toxicol 2012; 50(11): 3990-5.
[http://dx.doi.org/10.1016/j.fct.2012.08.016] [PMID: 22939932]
[11]
Stampfli L, Nersten B. Emulsifiers in bread making. Food Chem 1995; 52(4): 353-60.
[http://dx.doi.org/10.1016/0308-8146(95)93281-U]
[12]
Hasenhuettl GL. Overview of Food Emulsifiers. In: Hasenhuettl GL, Hartel RW, Eds. Food emulsifiers and their applications. New York: Springer 2008; pp. 1-9.
[13]
Biebaut D. Flour improvers and raising agents. In: Smith J, Ed. Food Additive User’s Handbook. Boston, MA: Springer 1991.
[14]
Kuhnert P. Food Additives Ullmann’s Encyclopedia of Industrial Chemistry 2016; pp. 1-52.
[15]
Laganà P, Campanella G, Patanè P, et al. Safety evaluation and assessment of gases for food applications. Chemistry and Hygiene of Food Gases. Cham: Springer 2019; pp. 41-50.
[http://dx.doi.org/10.1007/978-3-030-35228-8_4]
[16]
Deotale S, Dutta S, Moses JA, Balasubramaniam VM, Anandharamakrishnan C. Foaming characteristics of beverages and its relevance to food processing. Food Eng Rev 2020.
[http://dx.doi.org/10.1007/s12393-020-09213-4]
[17]
Pandey RM, Upadhyay SK. Food Additive. In: El-Samragy Y, Ed. Food Additive. Intechopen 2012; pp. 1-30.
[18]
Joshi A, Sagar VR, Sharma S, Singh B. Potentiality of potato flour as humectants (anti-staling agent) in bakery product: muffin. Potato Res 2018; 61: 115-31.
[http://dx.doi.org/10.1007/s11540-018-9362-7]
[19]
Jindal N, Singh Khattar J. Microbial polysaccharides in food industry. Biopolymers for Food Design 2018; pp. 95-123.
[http://dx.doi.org/10.1016/B978-0-12-811449-0.00004-9]
[20]
Sulieman AME-H. Gum arabic as thickener and stabilizing agents in dairy products Gum Arabic. 2018; pp. 151-65.
[http://dx.doi.org/10.1016/B978-0-12-812002-6.00013-0]
[21]
Prosapio V, Norton I. Simultaneous application of ultrasounds and firming agents to improve the quality properties of osmotic + freeze-dried foods. Lebensm Wiss Technol 2018; 96: 402-10.
[http://dx.doi.org/10.1016/j.lwt.2018.05.068]
[22]
Rojas-Graü MA, Tapia MS, Martín-Belloso O. Using polysaccharide-based edible coatings to maintain quality of fresh-cut Fuji apples. Lebensm Wiss Technol 2008; 41(1): 139-47.
[http://dx.doi.org/10.1016/j.lwt.2007.01.009]
[23]
Moslehi-Jenabian S, Pedersen LL, Jespersen L. Beneficial effects of probiotic and food borne yeasts on human health. Nutrients 2010; 2(4): 449-73.
[http://dx.doi.org/10.3390/nu2040449] [PMID: 22254033]
[24]
Colla K, Costanzo A, Gamlath S. Fat replacers in baked food products. Foods 2018; 7(12): 192.
[http://dx.doi.org/10.3390/foods7120192] [PMID: 30477253]
[25]
Saltmarsh M. Food additives and why they are used. Saltmarsh's essential guide to food additives 2020; 5: pp. 1-9.
[26]
Gultekin F, Doguc DK. Allergic and immunologic reactions to food additives. Clin Rev Allergy Immunol 2013; 45(1): 6-29.
[http://dx.doi.org/10.1007/s12016-012-8300-8] [PMID: 22278172]
[27]
Chazelas E, Deschasaux M, Srour B, et al. Food additives: distribution and co-occurrence in 126,000 food products of the French market. Sci Rep 2020; 10(1): 3980.
[http://dx.doi.org/10.1038/s41598-020-60948-w] [PMID: 32132606]
[28]
Awuchi CG, Twinomuhwezi H, Igwe VS, Amagwula IO. Food additives and food preservatives for domestic and industrial food applications. J Animal Health 2020; 2(1): 1-16.
[29]
Auerbach M, Craig S, Mitchell HL. Bulking Agents: Multi-Functional Ingredients. In: Mitchell HL, Ed. Sweeteners and Sugar Alternatives in Food Technology. Blackwell Publishing Ltd. 2007; pp. 365-400.
[30]
Beereboom JJ, Glicksman M. Low calorie bulking agents. CRC Crit Rev Food Sci Nutr 1979; 11(4): 401-13.
[http://dx.doi.org/10.1080/10408397909527269] [PMID: 378552]
[31]
Varlet V, Smith F, Augsburger M. New trends in the kitchen: propellants assessment of edible food aerosol sprays used on food. Food Chem 2014; 142: 311-7.
[http://dx.doi.org/10.1016/j.foodchem.2013.07.036] [PMID: 24001847]
[32]
Giri P, Pal C. An overview on the molecular aspects of food additives. Int J Chem and Life Sciences 2013; 02(08): 1207-12.
[33]
Porta R, Pandey A, Rosell CM. Enzymes as additives or processing aids in food biotechnology. Enzyme Res 2010; 1-2.
[http://dx.doi.org/10.4061/2010/436859] [PMID: 21528115]
[34]
Abdulmumeen HA, Risikat AN, Sururah AR. Food: Its preservatives, additives and applications. Int J Chem Biol Sci 2012; 1: 36-47.
[35]
Davidson PM, Sofos JN, Branen AL. Antimicrobials in food. (3rd [35] ed.). Boca Raton: CRC Press 2005.
[http://dx.doi.org/10.1201/9781420028737]
[36]
Arshad MS, Batool SA. Natural Antimicrobials, their Sources and Food Safety. In: Desiree NK, Geethi P, Eds. Food Additives. 2017.
[http://dx.doi.org/10.5772/intechopen.70197]
[37]
Doores S. pH Control Agents and Acidulants. In: Branen AL, Davidson PM, Salminen S, Thorngate J, Eds. Food Additives. New York: Marcel Dekker Inc. 2001.
[38]
Jacob M, Tripathi AM, Yadav G, Saha S. Nutritive and non-nutritive sweeteners: a review. Int J Oral Health Med Res 2016; 2(5): 149-53.
[39]
Campagnol PCB, dos Santos BA, Terra NN, Pollonio MAR. Lysine, disodium guanylate and disodium inosinate as flavor enhancers in low-sodium fermented sausages. Meat Sci 2012; 91(3): 334-8.
[http://dx.doi.org/10.1016/j.meatsci.2012.02.012] [PMID: 22391056]
[40]
Grummer J, Bobowski N, Karalus M, Vickers Z, Schoenfuss T. Use of potassium chloride and flavor enhancers in low sodium Cheddar cheese. J Dairy Sci 2013; 96(3): 1401-18.
[http://dx.doi.org/10.3168/jds.2012-6057] [PMID: 23332837]
[41]
Zhang F, Klebansky B, Fine RM, et al. Molecular mechanism of the sweet taste enhancers. Proc Natl Acad Sci USA 2010; 107(10): 4752-7.
[http://dx.doi.org/10.1073/pnas.0911660107] [PMID: 20173095]
[42]
Henry BS. Natural food colours. In: Hendry GAF, Houghton JD, Eds. Natural Food Colorants. Boston, MA: Springer 1996.
[http://dx.doi.org/10.1007/978-1-4615-2155-6_2]
[43]
Scotter MJ. Emerging and persistent issues with artificial food colours: natural colour additives as alternatives to synthetic colours in food and drink. Qual Assur Saf Crops Foods 2011; 3(1): 28-39.
[http://dx.doi.org/10.1111/j.1757-837X.2010.00087.x]
[44]
Prodolliet J, Bruelhart M. Determination of aspartame and its major decomposition products in foods. J AOAC Int 1993; 76(2): 275-82.
[http://dx.doi.org/10.1093/jaoac/76.2.275] [PMID: 8471853]
[45]
Tandel KR. Sugar substitutes: Health controversy over perceived benefits. J Pharmacol Pharmacother 2011; 2(4): 236-43.
[http://dx.doi.org/10.4103/0976-500X.85936] [PMID: 22025850]
[46]
Rother KI, Conway EM, Sylvetsky AC. How non-nutritive sweeteners influence hormones and health.trends. Trends Endocrinol Metab 2018; 29(7): 455-67.
[http://dx.doi.org/10.1016/j.tem.2018.04.010] [PMID: 29859661]
[47]
Stegink LD. The aspartame story: A model for the clinical testing of a food additive. Am J Clin Nutr 1987; 46(1)(Suppl.): 204-15.
[http://dx.doi.org/10.1093/ajcn/46.1.204] [PMID: 3300262]
[48]
Lin SY, Cheng YD. Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system. Food Addit Contam 2000; 17(10): 821-7.
[http://dx.doi.org/10.1080/026520300420385] [PMID: 11103265]
[49]
Rastogi S, Zakrzewski M, Suryanarayanan R. Investigation of solid-state reactions using variable temperature X-ray powder diffractrometry. I. Aspartame hemihydrate. Pharm Res 2001; 18(3): 267-73.
[http://dx.doi.org/10.1023/A:1011086409967] [PMID: 11442263]
[50]
Humphries P, Pretorius E, Naudé H. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr 2008; 62(4): 451-62.
[http://dx.doi.org/10.1038/sj.ejcn.1602866] [PMID: 17684524]
[51]
Adaramoye OA, Akanni OO. Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats. J Basic Clin Physiol Pharmacol 2016; 27(1): 29-37.
[http://dx.doi.org/10.1515/jbcpp-2014-0130] [PMID: 26247507]
[52]
Watkins JC. Excitatory amino acids and central synaptic transmission. Trends Pharmacol Sci 1984; 5: 373-6.
[http://dx.doi.org/10.1016/0165-6147(84)90474-7]
[53]
Stone TW, Burton NR. NMDA receptors and ligands in the vertebrate CNS. Prog Neurobiol 1988; 30(4): 333-68.
[http://dx.doi.org/10.1016/0301-0082(88)90027-5] [PMID: 2830636]
[54]
Rycerz K, Jaworska-Adamu JE. Effects of aspartame metabolites on astrocytes and neurons. Folia Neuropathol 2013; 51(1): 10-7.
[http://dx.doi.org/10.5114/fn.2013.34191] [PMID: 23553132]
[55]
Simintzi I, Schulpis KH, Angelogianni P, Liapi C, Tsakiris S. The effect of aspartame metabolites on the suckling rat frontal cortex acetylcholinesterase. An in vitro study. Food Chem Toxicol 2007; 45(12): 2397-401.
[http://dx.doi.org/10.1016/j.fct.2007.06.016] [PMID: 17673349]
[56]
Christian B, McConnaughey K, Bethea E, et al. Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+,K+-ATPase in rats. Pharmacol Biochem Behav 2004; 78(1): 121-7.
[http://dx.doi.org/10.1016/j.pbb.2004.02.017] [PMID: 15159141]
[57]
Tutelyan VA, Kravchenko LV, Kuzmina EE. The effect of aspartame on the activity of rat liver xenobiotic-metabolizing enzymes. Drug Metab Dispos 1990; 18(2): 223-5.
[PMID: 1971577]
[58]
Appleton KM, Rogers PJ, Blundell JE. Effects of a sweet and a nonsweet lunch on short-term appetite: differences in female high and low consumers of sweet/low-energy beverages. J Hum Nutr Diet 2004; 17(5): 425-34.
[http://dx.doi.org/10.1111/j.1365-277X.2004.00548.x] [PMID: 15357696]
[59]
Reid M, Hammersley R, Hill AJ, Skidmore P. Long-term dietary compensation for added sugar: effects of supplementary sucrose drinks over a 4-week period. Br J Nutr 2007; 97(1): 193-203.
[http://dx.doi.org/10.1017/S0007114507252705] [PMID: 17217576]
[60]
Van Wymelbeke V, Béridot-Thérond M-E, de La Guéronnière V, Fantino M. Influence of repeated consumption of beverages containing sucrose or intense sweeteners on food intake. Eur J Clin Nutr 2004; 58(1): 154-61.
[http://dx.doi.org/10.1038/sj.ejcn.1601762] [PMID: 14679381]
[61]
Anton SD, Martin CK, Han H, et al. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite 2010; 55(1): 37-43.
[http://dx.doi.org/10.1016/j.appet.2010.03.009] [PMID: 20303371]
[62]
Swithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab 2013; 24(9): 431-41.
[http://dx.doi.org/10.1016/j.tem.2013.05.005] [PMID: 23850261]
[63]
Feijó FM, Ballard CR, Foletto KC, et al. Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels. Appetite 2013; 60(1): 203-7.
[http://dx.doi.org/10.1016/j.appet.2012.10.009] [PMID: 23088901]
[64]
Swithers SE, Davidson TL. A role for sweet taste: calorie predictive relations in energy regulation by rats. Behav Neurosci 2008; 122(1): 161-73.
[http://dx.doi.org/10.1037/0735-7044.122.1.161] [PMID: 18298259]
[65]
Choudhary AK, Pretorius E. Revisiting the safety of aspartame. Nutr Rev 2017; 75(9): 718-30.
[http://dx.doi.org/10.1093/nutrit/nux035] [PMID: 28938797]
[66]
Choudhary AK, Devi RS. Effects of aspartame on hsp70, bcl-2 and bax expression in immune organs of Wistar albino rats. J Biomed Res 2016; 30(5): 427-35.
[PMID: 27845306]
[67]
Walker R, Lupien JR. The safety evaluation of monosodium glutamate. J Nutr 2000; 130(4S Suppl): 1049S-52S.
[http://dx.doi.org/10.1093/jn/130.4.1049S]
[68]
Husarova V, Ostatnikova D. Monosodium glutamate toxic effects and their implications for human intake: a review. J Med Res 2013; 2013: 1-12.
[http://dx.doi.org/10.5171/2013.608765]
[69]
Bera TK, Kar SK, Yadav PK, Mukherjee P, Yadav S, Joshi B. Effects of monosodium glutamate (MSG) on human health: A systematic review. World J Pharm Sci 2017; 5(5): 139-44.
[70]
Zhou Y, Rui L. Leptin signaling and leptin resistance. Front Med 2013; 7(2): 207-22.
[http://dx.doi.org/10.1007/s11684-013-0263-5] [PMID: 23580174]
[71]
Araujo TR, Freitas IN, Vettorazzi JF, et al. Benefits of L-alanine or L-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesity. Eur J Nutr 2017; 56(6): 2069-80.
[http://dx.doi.org/10.1007/s00394-016-1245-6] [PMID: 27317126]
[72]
He K, Du S, Xun P, et al. Consumption of monosodium glutamate in relation to incidence of overweight in Chinese adults: China Health and Nutrition Survey (CHNS). Am J Clin Nutr 2011; 93(6): 1328-36.
[http://dx.doi.org/10.3945/ajcn.110.008870] [PMID: 21471280]
[73]
Hermanussen M, Tresguerres JAF. Does high glutamate intake cause obesity? J Pediatr Endocrinol Metab 2003; 16(7): 965-8.
[http://dx.doi.org/10.1515/JPEM.2003.16.7.965] [PMID: 14513871]
[74]
Dawson R, Pelleymounter MA, Millard WJ, Liu S, Eppler B. Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage. Am J Physiol 1997; 273(1 Pt 1): E202-6.
[PMID: 9252497]
[75]
Hassan ZA, Arafa MH, Soliman WI, Atteia HH, Al-Saeed HF. The effects of monosodium glutamate on thymic and splenic immune functions and role of recovery (biochemical and histological study). J Cytol Histol 2014; 5(6): 1000283.
[http://dx.doi.org/10.4172/2157-7099.1000283]
[76]
Mustafa Z, Ashraf S, Tauheed SF, Ali S. Monosodium glutamate, commercial production, positive and negative effects on human body and remedies-a review. Int J Sci Eng Technol 2017; 3(4): 425-35.
[77]
Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000; 130(4S)(Suppl.): 1007S-15S.
[http://dx.doi.org/10.1093/jn/130.4.1007S] [PMID: 10736372]
[78]
Onyema OO, Farombi EO, Emerole GO, Ukoha AI, Onyeze GO. Effect of vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats. Indian J Biochem Biophys 2006; 43(1): 20-4.
[PMID: 16955747]
[79]
Kazmi Z, Fatima I, Perveen S, Malik SS. Monosodium glutamate: Review on clinical reports. Int J Food Prop 2017; 20(2): 1807-15.
[80]
White JS, Foreyt JP, Melanson KJ, Angelopoulos TJ. High-Fructose corn syrup: controversies and common sense. Am J Lifestyle Med 2010; 4(6): 515-20.
[http://dx.doi.org/10.1177/1559827610378960]
[81]
White JS. Sucrose, HFCS, and fructose: history, manufacture, composition, applications, and production. In: Rippe J, Ed. Fructose, High Fructose Corn Syrup, Sucrose and Health. New York: Nutrition and Health, Humana Press 2014; pp. 13-33.
[82]
Parker K, Salas M, Nwosu VC. High fructose corn syrup: Production, uses and public health concerns. Biotechnol Mol Biol Rev 2011; 5(5): 71-8.
[83]
Meyers AM, Mourra D, Beeler JA. High fructose corn syrup induces metabolic dysregulation and altered dopamine signaling in the absence of obesity. PLoS One 2017; 12(12): e0190206.
[http://dx.doi.org/10.1371/journal.pone.0190206] [PMID: 29287121]
[84]
Torres-Valadez R, Sandoval-Parra MG, Carrillo EAZ. Obesity and food addiction: consumption of high-fructose corn syrup and the effectiveness of clinical-nutritional management. Clinc 2020; 1(1): 01.
[85]
Farooqi IS, Keogh JM, Kamath S, et al. Partial leptin deficiency and human adiposity. Nature 2001; 414(6859): 34-5.
[http://dx.doi.org/10.1038/35102112] [PMID: 11689931]
[86]
Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 2002; 87(5): 2391-4.
[http://dx.doi.org/10.1210/jcem.87.5.8628] [PMID: 11994393]
[87]
Malik VS, Popkin BM, Bray GA, Després JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: A meta-analysis. Diabetes Care 2010; 33(11): 2477-83.
[http://dx.doi.org/10.2337/dc10-1079] [PMID: 20693348]
[88]
Bantle JP. Dietary fructose and metabolic syndrome and diabetes. J Nutr 2009; 139(6): 1263S-8S.
[http://dx.doi.org/10.3945/jn.108.098020] [PMID: 19403723]
[89]
Lustig RH, Schmidt LA, Brindis CD. Public health: The toxic truth about sugar. Nature 2012; 482(7383): 27-9.
[http://dx.doi.org/10.1038/482027a] [PMID: 22297952]
[90]
Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004; 79(4): 537-43.
[http://dx.doi.org/10.1093/ajcn/79.4.537] [PMID: 15051594]
[91]
Vos MB, McClain CJ. Fructose takes a toll. Hepatology 2009; 50(4): 1004-6.
[http://dx.doi.org/10.1002/hep.23212] [PMID: 19787819]
[92]
Santamaria P. Nitrate in vegetables: toxicity, content, intake and EC regulation. J Sci Food Agric 2005; 86(1): 10-7.
[http://dx.doi.org/10.1002/jsfa.2351]
[93]
van Velzen AG, Sips AJAM, Schothorst RC, Lambers AC, Meulenbelt J. The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett 2008; 181(3): 177-81.
[http://dx.doi.org/10.1016/j.toxlet.2008.07.019] [PMID: 18723086]
[94]
Joosen D, Stolk L, Henry R. A non-fatal intoxication with a high-dose sodium nitrate. BMJ Case Rep 2014; 2014: bcr2014204825.
[http://dx.doi.org/10.1136/bcr-2014-204825] [PMID: 24879739]
[95]
Harvey M, Cave G, Chanwai G. Fatal methaemoglobinaemia induced by self-poisoning with sodium nitrite. Emerg Med Australas 2010; 22(5): 463-5.
[http://dx.doi.org/10.1111/j.1742-6723.2010.01335.x] [PMID: 21040485]
[96]
Gautami S, Rao RN, Raghuram TC, Rajagopalan S, Bhat RV. Accidental acute fatal sodium nitrite poisoning. J Toxicol Clin Toxicol 1995; 33(2): 131-3.
[http://dx.doi.org/10.3109/15563659509000462] [PMID: 7897751]
[97]
Hughan KS, Levine A, Helbling N, et al. Effects of oral sodium nitrite on blood pressure, insulin sensitivity, and intima-media arterial thickening in adults with hypertension and metabolic syndrome. Hypertension 2020; 76(3): 866-74.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14930] [PMID: 32755471]
[98]
Micha R, Wallace SK, Mozaffarian D. Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: A systematic review and meta-analysis. Circulation 2010; 121(21): 2271-83.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.109.924977] [PMID: 20479151]
[99]
Hernández-Ramírez RU, Galván-Portillo MV, Ward MH, et al. Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City. Int J Cancer 2009; 125(6): 1424-30.
[http://dx.doi.org/10.1002/ijc.24454] [PMID: 19449378]
[100]
Ustyugova IV, Zeman C, Dhanwada K, Beltz LA. Nitrates/nitrites alter human lymphocyte proliferation and cytokine production. Arch Environ Contam Toxicol 2002; 43(3): 270-6.
[PMID: 12202921]
[101]
Pannala AS, Mani AR, Spencer JPE, et al. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Biol Med 2003; 34(5): 576-84.
[http://dx.doi.org/10.1016/S0891-5849(02)01353-9] [PMID: 12614846]
[102]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of sodium nitrate (E 251) and potassium nitrate (E 252) as food additives. EFSA J 2017; 15(6): e04787.
[PMID: 32625505]
[103]
Irwin SV, Fisher P, Graham E, Malek A, Robidoux A. Sulfites inhibit the growth of four species of beneficial gut bacteria at concentrations regarded as safe for food. PLoS One 2017; 12(10): e0186629.
[http://dx.doi.org/10.1371/journal.pone.0186629] [PMID: 29045472]
[104]
Freedman BJ. Sulphur dioxide in foods and beverages: its use as a preservative and its effect on asthma. Br J Dis Chest 1980; 74(2): 128-34.
[http://dx.doi.org/10.1016/0007-0971(80)90023-6] [PMID: 7426352]
[105]
Wüthrich B, Huwyler T. Asthma due to disulfites. Schweiz Med Wochenschr 1989; 119(35): 1177-84.
[PMID: 2799334]
[106]
Reno AL, Brooks EG, Ameredes BT. Mechanisms of heightened airway sensitivity and responses to inhaled SO2 in asthmatics. Environ Health Insights 2015; 9(Suppl. 1): 13-25.
[PMID: 25922579]
[107]
Samadder A, Chakraborty D, De A, Bhattacharyya SS, Bhadra K, Khuda-Bukhsh AR. Possible signaling cascades involved in attenuation of alloxan-induced oxidative stress and hyperglycemia in mice by ethanolic extract of Syzygium jambolanum: drug-DNA interaction with calf thymus DNA as target. Eur J Pharm Sci 2011; 44(3): 207-17.
[http://dx.doi.org/10.1016/j.ejps.2011.07.012] [PMID: 21839831]
[108]
Samadder A, Dey S, Sow P, et al. Phyto-chlorophyllin prevents food additive induced genotoxicity and mitochondrial dysfunction via cytochrome c mediated pathway in mice model. Comb Chem High Throughput Screen 2020; 24(10): 1618-27.
[PMID: 33380297]
[109]
Ighodaro OM, Adeosun AM, Akinloye OA. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina (Kaunas) 2017; 53(6): 365-74.
[http://dx.doi.org/10.1016/j.medici.2018.02.001] [PMID: 29548636]
[110]
Dunn JS, Kirkpatrick J, McLetchie NGB, Telfer SV. Necrosis of the islets of Langerhans produced experimentally. J Pathol Bacteriol 1943; 55(3): 245-57.
[http://dx.doi.org/10.1002/path.1700550302]
[111]
Samadder A, Abraham SK, Khuda-Bukhsh AR. Nanopharmaceutical approach using pelargonidin towards enhancement of efficacy for prevention of alloxan-induced DNA damage in L6 cells via activation of PARP and p53. Environ Toxicol Pharmacol 2016; 43: 27-37.
[http://dx.doi.org/10.1016/j.etap.2016.02.010] [PMID: 26943895]
[112]
Samadder A, Tarafdar D, Abraham SK, Ghosh K, Khuda-Bukhsh AR. Nano-pelargonidin protects hyperglycemic-induced l6 cells against mitochondrial dysfunction. Planta Med 2017; 83(5): 468-75.
[http://dx.doi.org/10.1055/s-0043-100017] [PMID: 28073120]
[113]
Dey R, Nandi S, Samadder A. Pelargonidin mediated selective activation of p53 and parp proteins in preventing food additive induced genotoxicity: An in vivo coupled in silico molecular docking study. Eur J Pharm Sci 2021; 156(156): 105586.
[http://dx.doi.org/10.1016/j.ejps.2020.105586] [PMID: 33039567]
[114]
Glass EJ, Stewart J, Weir DM. Altered immune function in alloxan-induced diabetes in mice. Clin Exp Immunol 1986; 65(3): 614-21.
[PMID: 3780043]
[115]
Spencer M. Food additives. Postgrad Med J 1974; 50(588): 620-4.
[http://dx.doi.org/10.1136/pgmj.50.588.620] [PMID: 4467857]
[116]
Heimbach J, Rieth S, Mohamedshah F, et al. Safety assessment of iron EDTA [sodium iron (Fe(3+) ethylenediaminetetraacetic acid: summary of toxicological, fortification and exposure data. Food Chem Toxicol 2000; 38(1): 99-111.
[http://dx.doi.org/10.1016/S0278-6915(99)00125-8] [PMID: 10685019]
[117]
Wreesmann CTJ. Reasons for raising the maximum acceptable daily intake of EDTA and the benefits for iron fortification of foods for children 6-24 months of age. Matern Child Nutr 2014; 10(4): 481-95.
[http://dx.doi.org/10.1111/mcn.12110] [PMID: 24521261]
[118]
Alfadul SM, Elneshwy AA. Use of nanotechnology in food processing, packaging and safety-review. Afr J Food Agric Nutr Dev 2010; 10(6): 2719-39.
[http://dx.doi.org/10.4314/ajfand.v10i6.58068]
[119]
Manning L. Food and Drink - Good Manufacturing Practice - A Guide to its responsible management. 6th ed. John Wiley & Sons, Ltd. 2012; p. 280.
[120]
U.S. Food and Drug and Administration. Small entity compliance guide: current good manufacturing practice in manufacturing, packaging, labeling, or holding operations for dietary supplements 2018. Reference: Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/small-entity-compliance-guide-current-good-manufacturing-practice-manufacturing-packaging-labeling.’ (Published on 20 September 2018).
[121]
Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US) 2001. Reference: Available from: https://www.ncbi.nlm.nih.gov/books/NBK222310/’
[122]
Carpenter TO, Pettifor JM, Russell RM, et al. Severe hypervitaminosis A in siblings: evidence of variable tolerance to retinol intake. J Pediatr 1987; 111(4): 507-12.
[http://dx.doi.org/10.1016/S0022-3476(87)80109-9] [PMID: 3655980]
[123]
Scientific opinion on the tolerable upper intake level of vitamin D. EFSA J 2012; 10(7): 2813.
[http://dx.doi.org/10.2903/j.efsa.2012.2813]
[124]
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US) 1998. Reference: Available from: https://www.ncbi.nlm.nih.gov/books/NBK114310/’
[125]
Field MS, Stover PJ. Safety of folic acid. Ann N Y Acad Sci 2018; 1414(1): 59-71.
[http://dx.doi.org/10.1111/nyas.13499] [PMID: 29155442]
[126]
Scientific panel on dietetic products. Nutrition and Allergies (NDA). Tolerable upper intake levels for vitamins and minerals. EFSA J 2006.
[127]
Hathcock JN, Azzi A, Blumberg J, et al. Vitamins E and C are safe across a broad range of intakes. Am J Clin Nutr 2005; 81(4): 736-45.
[http://dx.doi.org/10.1093/ajcn/81.4.736] [PMID: 15817846]
[128]
Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F. The role of vitamin e in human health and some diseases. Sultan Qaboos Univ Med J 2014; 14(2): e157-65.
[PMID: 24790736]
[129]
Kaur N, Chugh V, Gupta AK. Essential fatty acids as functional components of foods- a review. J Food Sci Technol 2014; 51(10): 2289-303.
[http://dx.doi.org/10.1007/s13197-012-0677-0] [PMID: 25328170]
[130]
Scientific Opinion related to the Tolerable Upper Intake Level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA). EFSA J 2012; 10(7): 2815.
[131]
Kanduti D, Sterbenk P, Artnik B. Fluoride: A review of use and effects on health. Mater Sociomed 2016; 28(2): 133-7.
[http://dx.doi.org/10.5455/msm.2016.28.133-137] [PMID: 27147921]
[132]
Leung AM, Braverman LE. Consequences of excess iodine. Nat Rev Endocrinol 2014; 10(3): 136-42.
[http://dx.doi.org/10.1038/nrendo.2013.251] [PMID: 24342882]
[133]
AzehEngwa G, Udoka Ferdinand P, Nweke NF, Unachukwu M. Mechanism and health effects of heavy metal toxicity in humans. Poisoning in the Modern World - New Tricks for an Old Dog?. IntechOpen 2019.
[134]
Schwalfenberg GK, Genuis SJ. The importance of magnesium in clinical healthcare. Scientifica (Cairo) 2017; 2017: 4179326.
[http://dx.doi.org/10.1155/2017/4179326] [PMID: 29093983]
[135]
Razzaque MS. Phosphate toxicity: new insights into an old problem. Clin Sci (Lond) 2011; 120(3): 91-7.
[http://dx.doi.org/10.1042/CS20100377] [PMID: 20958267]
[136]
Farquhar WB, Edwards DG, Jurkovitz CT, Weintraub WS. Dietary sodium and health: more than just blood pressure. J Am Coll Cardiol 2015; 65(10): 1042-50.
[http://dx.doi.org/10.1016/j.jacc.2014.12.039] [PMID: 25766952]
[137]
Nriagu J. Zinc toxicity in humans In: Encyclopedia of Environmental Health. 2011; pp. 801-7.
[http://dx.doi.org/10.1016/B978-0-444-52272-6.00675-9]
[138]
Scientific Committee on Health, Environmental and Emerging Risks. Final Opinion on tolerable intake of aluminium with regards to adapting the migration limits for aluminium in toys. 2017.
[139]
63rd JECFA - Chemical and Technical Assessment (CTA). Benzoyl Peroxide 2004. Reference: Available from: http://www.fao.org/3/at985e/at985e.pdf’(First draft prepared by Yehia El-Samragy)
[140]
Smith J, Hong-Shum L. Food additives data book. (2nd ed). West Sussex: Wiley & Sons Ltd. 2011.
[http://dx.doi.org/10.1002/9781444397741]
[141]
Safety of gaseous chlorine dioxide as a preservative slowly released in cold food storage areas. EFSA J 2016; 14(2)
[142]
Scientific opinion on the safety and efficacy of citric acid when used as a technological additive (preservative) for all animal species. EFSA J 2015; 13(2): 4009.
[143]
Younes M, Aquilina G, Castle L, et al. Re-evaluation of acetic acid, lactic acid, citric acid, tartaric acid, mono- and diacetyltartaric acid, mixed acetic and tartaric acid esters of mono- and diglycerides of fatty acids (E 472a-f) as food additives. EFSA J 2020; 18(3): e06032.
[PMID: 32874250]
[144]
Younes M, Aquilina G, Castle L, et al. Re-evaluation of phosphoric acid-phosphates - di-, tri- and polyphosphates (E 338-341, E 343, E 450-452) as food additives and the safety of proposed extension of use. EFSA J 2019; 17(6): e05674.
[PMID: 32626329]
[145]
Rychen G, Aquilina G, Azimonti G, et al. Safety and efficacy of bentonite as a feed additive for all animal species. EFSA J 2017; 15(12): e05096.
[PMID: 32625382]
[146]
Kurokawa Y, Hayashi Y, Maekawa A, Takahashi M, Kokubo T, Odashima S. Carcinogenicity of potassium bromate administered orally to F344 rats. J Natl Cancer Inst 1983; 71(5): 965-72.
[PMID: 6580498]
[147]
El Ati-Hellal M, Doggui R, Krifa Y, El Ati J. Potassium bromate as a food additive: A case study of Tunisian breads. Environ Sci Pollut Res Int 2018; 25(3): 2702-6.
[http://dx.doi.org/10.1007/s11356-017-0712-9] [PMID: 29134528]
[148]
Kurokawa Y, Maekawa A, Takahashi M, Hayashi Y. Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen. Environ Health Perspect 1990; 87: 309-35.
[PMID: 2269236]
[149]
Scientific Opinion on the safety assessment of the active substances, sodium erythorbate, sodium carbonate, sodium bicarbonate, iron sulphate, activated carbon, cellulose, calcium hydroxide, calcium chloride and water, for use as active system in food contact materials. EFSA J 2014; 12(2): 3571.
[150]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of glycerol (E 422) as a food additive. EFSA J 2017; 15(3): e04720.
[PMID: 32625431]
[151]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of pectin (E 440i) and amidated pectin (E 440ii) as food additives. EFSA J 2017; 15(7): e04866.
[PMID: 32625540]
[152]
Younes M, Aggett P, Aguilar F, et al. Re-evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives. EFSA J 2018; 16(4): e05238.
[PMID: 32625873]
[153]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of agar (E 406) as a food additive. EFSA J 2016; 14(2): e04645.
[154]
Younes M, Aggett P, Aguilar F, et al. Re-evaluation of alginic acid and its sodium, potassium, ammonium and calcium salts (E 400-E 404) as food additives. EFSA J 2017; 15(11): e05049.
[PMID: 32625343]
[155]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of guar gum (E 412) as a food additive. EFSA J 2017; 15(2): e04669.
[PMID: 32625396]
[156]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of locust bean gum (E 410) as a food additive. EFSA J 2017; 15(1): e04646.
[PMID: 32625248]
[157]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of xanthan gum (E 415) as a food additive. EFSA J 2017; 15(7): e04909.
[PMID: 32625570]
[158]
Younes M, Aggett P, Aguilar F, et al. Re-evaluation of gellan gum (E 418) as food additive. EFSA J 2018; 16(6): e05296.
[PMID: 32625935]
[159]
Younes M, Aquilina G, Castle L, et al. Re-evaluation of hydrochloric acid (E 507), potassium chloride (E 508), calcium chloride (E 509) and magnesium chloride (E 511) as food additives. EFSA J 2019; 17(7): e05751.
[PMID: 32626371]
[160]
Safety and efficacy of lactic acid and calcium lactate when used as technological additives for all animal species. EFSA J 2015; 13(12)
[161]
Scientific Opinion on re-evaluation of calcium carbonate (E 170) as a food additive. EFSA J 2011; 9(7): 2318.
[162]
Aguilar F, Charrondiere U, Dusemund B, et al. Calcium sulphate for use as a source of calcium in food supplements. EFSA J 2008; 814: 1-9.
[163]
Scientific opinion on flavouring group evaluation 46, revision 1 (FGE.46Rev1): Ammonia and three ammonium salts from chemical group 30. EFSA J 2011; 9(2): 1925.
[http://dx.doi.org/10.2903/j.efsa.2011.1925]
[164]
Freston JW, Ahnen DJ, Czinn SJ, et al. Review and analysis of the effects of olestra, a dietary fat substitute, on gastrointestinal function and symptoms. Regul Toxicol Pharmacol 1997; 26(2): 210-8.
[http://dx.doi.org/10.1006/rtph.1997.1165] [PMID: 9356284]
[165]
Webb DR, Wood FE, Bertram TA, Fortier NE. A 91-day feeding study in rats with caprenin. Food Chem Toxicol 1993; 31(12): 935-46.
[http://dx.doi.org/10.1016/0278-6915(93)90002-G] [PMID: 8282277]
[166]
Smith RE, Finley JW, Leveille GA. Overview of SALATRIM: A family of low-calorie fats. J Agric Food Chem 1994; 42(2): 432-4.
[http://dx.doi.org/10.1021/jf00038a036]
[167]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Beewax Reference: Available from: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=168’
[168]
65th JECFA - Chemical and Technical Assessment (CTA). Candelilla wax 2005. Reference: Available from: http://www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/65/candelillla_wax.pdf (First draft prepared by Paul M. Kuznesof).
[169]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Shellac, Bleached Reference: Available from: https://apps.who.int/food-additives-contaminants-jecfa database/chemical.aspx?chemID=216
[170]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA).. Carnauba Wax. Available from: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=939’
[171]
Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive. EFSA J 2012; 10(10): 2880.
[172]
Scientific Opinion on the re-evaluation of candelilla wax (E 902) as a food additive. EFSA J 2012; 10(10): 2946.
[173]
Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of fatty acids (E 570) as a food additive. EFSA J 2017; 15(5): 4785.
[174]
Scientific Opinion on the re-evaluation of microcrystalline wax (E 905) as a food additive. EFSA J 2013; 11(4): 3146.
[175]
Younes M, Aquilina G, Castle L, et al. Re-evaluation of l(+)-tartaric acid (E 334), sodium tartrates (E 335), potassium tartrates (E 336), potassium sodium tartrate (E 337) and calcium tartrate (E 354) as food additives. EFSA J 2020; 18(3): e06030.
[PMID: 32874248]
[176]
Yokel RA. Aluminum in food - the nature and contribution of food additives. Food Additive 2012; 203-28.
[177]
Aluminium Ammonium Sulfate and Aluminium Potassium Sulfate (Food Additives). Food Safety 2019; 7(3): 79-82.
[http://dx.doi.org/10.14252/foodsafetyfscj.D-19-00015] [PMID: 31998591]
[178]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Ammonium Hydrogen Carbonate Available from: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=133’
[179]
Zhang H, Zhang JY, Wang HL, Luo PJ, Zhang JB. The revision of aluminum-containing food additive provisions in China. Biomed Environ Sci 2016; 29(6): 461-6.
[PMID: 27470109]
[180]
Younes M, Aggett P, Aguilar F, et al. Re-evaluation of aluminium sulphates (E 520-523) and sodium aluminium phosphate (E 541) as food additives. EFSA J 2018; 16(7): e05372.
[PMID: 32625999]
[181]
Tenny S, Patel R, Thorell W. Mannitol. StatPearls [Internet]. StatPearls Publishing: Treasure Island (FL) 2021.
[182]
Dobreva V, Hadjikinova M, Slavov A, Hadjikinov D, Dobrev G, Zhekova B. Functional properties of maltitol. Agric Sci Technol 2013; 5(2): 168-72.
[183]
Scientific Opinion on the re-evaluation of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives. EFSA J 2015; 13(5): 4087.
[184]
Rychen G, Aquilina G, Azimonti G, et al. Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species. EFSA J 2018; 16(3): e05215.
[PMID: 32625845]
[185]
Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive. EFSA J 2012; 10(3): 2588.
[186]
Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives.. Evaluation of certain Food Additives and Contaminants Available from: https://apps.who.int/iris/bitstream/handle/10665/42142/WHO_TRS_884.pdf?sequence=1’
[187]
Doyle ME, Glass KA. Sodium reduction and its effect on food safety, food quality, and human health. Compr Rev Food Sci Food Saf 2010; 9(1): 44-56.
[http://dx.doi.org/10.1111/j.1541-4337.2009.00096.x] [PMID: 33467812]
[188]
Scientific Opinion on the safety and efficacy of acetic acid, sodium diacetate and calcium acetate as preservatives for feed for all animal species. EFSA J 2013; 10(2): 2571.
[189]
Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives. EFSA J 2016; 14(3): 4433.
[190]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Lactic Acid 2007. Available from: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=3367’ [191] Sixty-seventh report of the Joint FAO/WHO
[191]
Sixty-seventh report of the Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain Food Additives and Contaminants 2007. Available from: https://apps.who.int/iris/handle/10665/43592.
[192]
Fiume MM, Heldreth BA, Bergfeld WF, et al. Safety assessment of citric acid, inorganic citrate salts, and alkyl citrate esters as used in cosmetics. Int J Toxicol 2014; 33(2)(Suppl.): 16S-46S.
[http://dx.doi.org/10.1177/1091581814526891] [PMID: 24861367]
[193]
Scientific Opinion on the safety and efficacy of sodium carbonate (soda ash) for all species. EFSA J 2010; 8(7): 1695.
[http://dx.doi.org/10.2903/j.efsa.2010.1695]
[194]
Metwaly A, Aboul-Enein A, Abd-Allah A, Hanafy E. Do synthetic food additives possess higher genotoxic effect than natural ones? Biosci Res 2018; 15(4): 3329-36.
[195]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Ethyl Acetate Reference: Available from: https://www.iprecio.com/products/tabid/245/Default.aspx
[196]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Ethyl Butyrate Available from: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=106’
[197]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Methyl Anthranilate Available from: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=5278’
[198]
Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species. EFSA J 2011; 9(12): 2441.
[http://dx.doi.org/10.2903/j.efsa.2011.2441]
[199]
Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Ethyl Formate Available from: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=3454’
[200]
Whitehouse CR, Boullata J, McCauley LA. The potential toxicity of artificial sweeteners. AAOHN J 2008; 56(6): 251-9.
[http://dx.doi.org/10.1177/216507990805600604] [PMID: 18604921]
[201]
Magnuson BA, Burdock GA, Doull J, et al. Aspartame: A safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol 2007; 37(8): 629-727.
[http://dx.doi.org/10.1080/10408440701516184] [PMID: 17828671]
[202]
Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice. Front Physiol 2017; 8: 487.
[http://dx.doi.org/10.3389/fphys.2017.00487] [PMID: 28790923]
[203]
Duncan TV. Applications of nanotechnology in food packaging and food safety: barrier materials, antimicrobials and sensors. J Colloid Interface Sci 2011; 363(1): 1-24.
[http://dx.doi.org/10.1016/j.jcis.2011.07.017] [PMID: 21824625]
[204]
Singh T, Shukla S, Kumar P, Wahla V, Bajpai VK, Rather IA. Application of nanotechnology in food science: perception and overview. Front Microbiol 2017; 8: 1501.
[http://dx.doi.org/10.3389/fmicb.2017.01501] [PMID: 28824605]
[205]
Sozer N, Kokini JL. Nanotechnology and its applications in the food sector. Trends Biotechnol 2009; 27(2): 82-9.
[http://dx.doi.org/10.1016/j.tibtech.2008.10.010] [PMID: 19135747]
[206]
Khan MI, Shoukat MA, Bilal U, Iqbal S. Nanotechniques Used In Food Industries: A Mini Review. J Food Biotechnol Res 2018; 2(1): 6.
[207]
Chellaram C, Murugaboopathi G, John AA, et al. Significance of nanotechnology in food industry. APCBEE Procedia 2014; 8: 109-13.
[http://dx.doi.org/10.1016/j.apcbee.2014.03.010]
[208]
Ahmed K, Li Y, McClements DJ, Xiao H. Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties. Food Chem 2012; 132(2): 799-807.
[http://dx.doi.org/10.1016/j.foodchem.2011.11.039] [PMID: 22868161]
[209]
Bhushani JA, Karthik P, Anandharamakrishnan C. Nanoemulsion based delivery system for improved bioaccessibility and Caco-2 cell monolayer permeability of green tea catechins. Food Hydrocoll 2016; 56: 372-82.
[http://dx.doi.org/10.1016/j.foodhyd.2015.12.035]
[210]
Qian C, Decker EA, Xiao H, McClements DJ. Nanoemulsion delivery systems: influence of carrier oil on β-carotene bioaccessibility. Food Chem 2012; 135(3): 1440-7.
[http://dx.doi.org/10.1016/j.foodchem.2012.06.047] [PMID: 22953878]
[211]
Bumbudsanpharoke N, Ko S. Nanoclays in food and beverage packaging. J Nanomater 2019; 2019
[http://dx.doi.org/10.1155/2019/8927167]
[212]
He X, Hwang HM. Nanotechnology in food science: Functionality, applicability, and safety assessment. J Food Drug Anal 2016; 24(4): 671-81.
[http://dx.doi.org/10.1016/j.jfda.2016.06.001] [PMID: 28911604]
[213]
Li X, Li W, Jiang Y, et al. Effect of nano-ZnO-coated active packaging on quality of fresh-cut “Fuji” apple. Int J Food Sci Technol 2011; 46(9): 1947-55.
[http://dx.doi.org/10.1111/j.1365-2621.2011.02706.x]
[214]
Biji KB, Ravishankar CN, Mohan CO, Srinivasa Gopal TK. Smart packaging systems for food applications: A review. J Food Sci Technol 2015; 52(10): 6125-35.
[http://dx.doi.org/10.1007/s13197-015-1766-7] [PMID: 26396360]
[215]
Brandelli A. The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity. Food Sci Hum Wellness 2020; 9(1): 8-10.
[http://dx.doi.org/10.1016/j.fshw.2019.12.003]
[216]
Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov 2020.
[PMID: 33277608]
[217]
Luo Y-H, Chang LW, Lin P. Metal-Based nanoparticles and the immune system: Activation, inflammation, and ptential applications. BioMed Res Int 2015; 2015: 1-12.
[http://dx.doi.org/10.1155/2015/143720]
[218]
Vandghanooni S, Forouharmehr A, Eskandani M, et al. Cytotoxicity and DNA fragmentation properties of butylated hydroxyanisole. DNA Cell Biol 2013; 32(3): 98-103.
[http://dx.doi.org/10.1089/dna.2012.1946] [PMID: 23413972]
[219]
Jeong SH, Kim BY, Kang HG, Ku HO, Cho JH. Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats. Toxicology 2005; 208(1): 49-62.
[http://dx.doi.org/10.1016/j.tox.2004.11.014] [PMID: 15664432]
[220]
Kharkar PS, Warrier S, Gaud RS. Reverse docking: A powerful tool for drug repositioning and drug rescue. Future Med Chem 2014; 6(3): 333-42.
[http://dx.doi.org/10.4155/fmc.13.207] [PMID: 24575968]
[221]
Cereto-Massagué A, Ojeda MJ, Valls C, Mulero M, Pujadas G, Garcia-Vallve S. Tools for in silico target fishing. Methods 2015; 71: 98-103.
[http://dx.doi.org/10.1016/j.ymeth.2014.09.006] [PMID: 25277948]
[222]
Schuffenhauer A, Floersheim P, Acklin P, Jacoby E. Similarity metrics for ligands reflecting the similarity of the target proteins. J Chem Inf Comput Sci 2003; 43(2): 391-405.
[http://dx.doi.org/10.1021/ci025569t] [PMID: 12653501]
[223]
Hawkins PCD, Skillman AG, Nicholls A. Comparison of shape-matching and docking as virtual screening tools. J Med Chem 2007; 50(1): 74-82.
[http://dx.doi.org/10.1021/jm0603365] [PMID: 17201411]
[224]
Huang H, Zhang G, Zhou Y, et al. Reverse screening methods to search for the protein targets of chemopreventive compounds. Front Chem 2018; 6: 138.
[http://dx.doi.org/10.3389/fchem.2018.00138] [PMID: 29868550]
[225]
Patel H, Lucas X, Bendik I, Günther S, Merfort I. Target fishing by cross-docking to explain polypharmacological effects. ChemMedChem 2015; 10(7): 1209-17.
[http://dx.doi.org/10.1002/cmdc.201500123] [PMID: 26033840]
[226]
Steindl TM, Schuster D, Laggner C, Langer T. Parallel screening: A novel concept in pharmacophore modeling and virtual screening. J Chem Inf Model 2006; 46(5): 2146-57.
[http://dx.doi.org/10.1021/ci6002043] [PMID: 16995745]
[227]
Lee A, Lee K, Kim D. Using reverse docking for target identification and its applications for drug discovery. Expert Opin Drug Discov 2016; 11(7): 707-15.
[http://dx.doi.org/10.1080/17460441.2016.1190706] [PMID: 27186904]

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