Abstract
SO2 is emerging as a possible endogenous signaling molecule in mammals. In addition, SO2 has also shown pharmacological effects, presenting SO2 as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO2 prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO2 prodrug design. The remaining challenges and issues will also be discussed.
Keywords: Sulfur dioxide, Prodrugs, Drug delivery, Gasotransmitter, Donors, Click and release.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics
Volume: 21 Issue: 32
Author(s): Eman M El-Labbad*, Xingyue Ji*, Khaled A.M. Abouzid and Binghe Wang
Affiliation:
- Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566, Cairo,Egypt
- Department of Medicinal Chemistry, College of Pharmaceutical Science, Soochow University, 215123, Suzhou,China
Keywords: Sulfur dioxide, Prodrugs, Drug delivery, Gasotransmitter, Donors, Click and release.
Abstract: SO2 is emerging as a possible endogenous signaling molecule in mammals. In addition, SO2 has also shown pharmacological effects, presenting SO2 as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO2 prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO2 prodrug design. The remaining challenges and issues will also be discussed.
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Cite this article as:
El-Labbad M Eman *, Ji Xingyue *, Abouzid A.M. Khaled and Wang Binghe , Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics, Current Topics in Medicinal Chemistry 2021; 21 (32) . https://dx.doi.org/10.2174/1568026621666211116091354
DOI https://dx.doi.org/10.2174/1568026621666211116091354 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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