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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics

Author(s): Eman M El-Labbad*, Xingyue Ji*, Khaled A.M. Abouzid and Binghe Wang

Volume 21, Issue 32, 2021

Published on: 10 December, 2021

Page: [2870 - 2881] Pages: 12

DOI: 10.2174/1568026621666211116091354

Price: $65

Abstract

SO2 is emerging as a possible endogenous signaling molecule in mammals. In addition, SO2 has also shown pharmacological effects, presenting SO2 as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO2 prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO2 prodrug design. The remaining challenges and issues will also be discussed.

Keywords: Sulfur dioxide, Prodrugs, Drug delivery, Gasotransmitter, Donors, Click and release.

Graphical Abstract


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