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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Research Article

Study on the Effects of Kuanxiong Aerosol on the Isolated Artery and Rabbits Acute Myocardial Ischemia Model

Author(s): Xia Liu, Feihua Huang, Xiao Lu, Yuji Wang, Tingting Cai, Aiping Peng and Wanping Zhu*

Volume 25, Issue 9, 2022

Published on: 12 January, 2022

Page: [1534 - 1544] Pages: 11

DOI: 10.2174/1386207324666210811142312

Price: $65

Abstract

Background: Kuan Xiong aerosol (KXA) is a Chinese herbal compound used to regulate qi-flowing to relieve pain and improve angina. However, only a few pharmacological studies on this traditional Chinese medicine preparation have been reported to confirm these activities.

Objectives: This article aims to observe the effect of resisting acute myocardial ischemia (AMI) in vivo and dilating vessel in vitro of KXA.

Methods: The AMI model involves intravenously injecting the pituitary (2 U.kg-1) into the ear of rabbits. Electrocardiograph (ECG) T waves were then recorded after administration, and the falling range was calculated. Following this, the level of serum Cardiac troponin T (cTn-T) and the histopathology of the cardiac muscle tissue were evaluated. In vitro, the effect of KXA on vasodilation of isolated aortic rings that had been pre-contracted with KCl (30 mM) was observed.

Results: It was found that KXA reduced ECG ST-T waves and serum cTn-T in the rabbit AMI model, protecting myocardial tissue from fracturing and loss of myocardial fibers and inhibiting inflammatory cell infiltration, cavitation degeneration, and karyopyknosis of the myocardial matrix. Furthermore, the administration of 0.215, 1.075, and 2.150 mg.mL-1 of KXA resulted in significant relaxation of the aortic rings at a rate of 69.63 %, 90.14 %, and 118.72 % (p < 0.01) in the untreated ones, and a second shrinkage ratio of 20.17 %, 4.29 %, and 4.54 % (p < 0.01) in the untreated ones, respectively.

Conclusion: These results suggest that KXA protects against AMI, contributes to the dilation of blood vessels, and has long-acting effectiveness.

Keywords: Kuan xiong aerosol, volatile oils, acute myocardial ischemia, myocardial injury, vasodilatation, cardiac troponin T.

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