Abstract
Coumarin-based derivatives have easy modification and tunable properties and have been synthesized and applied in many areas including pro-drugs, biomedical materials, and chemical and biological sensing. In this review, recent advances of coumarin-based fluorescent probes for biosensing are reported for metal ion imaging. Metal detection in living cells are highlighted with representative examples together with fluorescence response mechanisms such as Photoinduced Electron Transfer (PET), Intramolecular Charge Transfer (ICT), and Fluorescence Resonance Energy Transfer (FRET). Some future perspectives are also briefly mentioned.
Keywords: Coumarins, fluorescent probe, mechanism, metal, bioimaging, cells.
Graphical Abstract
Current Organic Chemistry
Title:Coumarin-based Fluorescent Probes for Bioimaging: Recent Applications and Developments
Volume: 25 Issue: 18
Author(s): Jinhua Xie, Le Wang *, Xiqi Su and Joáo Rodrigues*
Affiliation:
- College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620,China
- CQM - Centro de Quimica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal,Portugal
Keywords: Coumarins, fluorescent probe, mechanism, metal, bioimaging, cells.
Abstract: Coumarin-based derivatives have easy modification and tunable properties and have been synthesized and applied in many areas including pro-drugs, biomedical materials, and chemical and biological sensing. In this review, recent advances of coumarin-based fluorescent probes for biosensing are reported for metal ion imaging. Metal detection in living cells are highlighted with representative examples together with fluorescence response mechanisms such as Photoinduced Electron Transfer (PET), Intramolecular Charge Transfer (ICT), and Fluorescence Resonance Energy Transfer (FRET). Some future perspectives are also briefly mentioned.
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Cite this article as:
Xie Jinhua , Wang Le *, Su Xiqi and Rodrigues Joáo *, Coumarin-based Fluorescent Probes for Bioimaging: Recent Applications and Developments, Current Organic Chemistry 2021; 25 (18) . https://dx.doi.org/10.2174/1385272825666210728101823
DOI https://dx.doi.org/10.2174/1385272825666210728101823 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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