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ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

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Review Article

The Use of Cannabis and Cannabinoid-based Products by Pregnant Women: A Patent Review

Author(s): Diana Babini Lapa de Albuquerque Britto*, Fernanda das Chagas Angelo Mendes Tenorio, Bruno Tenorio, Larissa Rolim and Valdemiro Silva Júnior

Volume 15, Issue 3, 2021

Published on: 19 July, 2021

Page: [184 - 194] Pages: 11

DOI: 10.2174/1872208315666210719110606

Price: $65

Abstract

Plants of the genus Cannabis have been gaining attention in medicine. The most outstanding treatments include antispasmodic, analgesic, antiemetic, neuroprotective and anti-inflammatory actions. The aim of the study was to describe patents associated with cannabis and cannabinoids as a treatment for pregnant women. A search was carried out on four patent bases: National Institute of Industrial Property, Latipat, Espacenet and Patentscope. The used search keys were “Cannabis”, “Cannabidiol”, “Cannabinoids”, “CBD” and “THC” associated with “pregnant women”. Patents in any language and year were considered. A total of 1,402 patents were found in all the used databases. After reading the title and abstract, patents were excluded if they did not meet the eligibility criteria and/or if they were duplicates, thus leaving 11 patents on the use of cannabis and/or cannabinoids as treatment in pregnant women. A critical analysis was carried out. All selected patents were from the Asian continent (China), focusing on traditional Chinese medicine for treating various possible changes during pregnancy and also for diseases prevention in the postpartum period. It was found that the main causes for the need of such treatments were related to spleen deficiencies, inability and/or moisture stagnation. Finally, the vast majority of treatments used Cannabis fruits associated with other plants. Given the above, patents related to cannabis and cannabinoids for the treatment of pregnant women in the peri and postnatal periods were found to be associated with traditional Chinese medicine.

Keywords: Cannabidiol, CBD, THC, pregnant women, pregnancy, puerperium.

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Graphical Abstract

[1]
Ben Amar M. Cannabinoids in medicine: A review of their therapeutic potential. J Ethnopharmacol 2006; 105(1-2): 1-25.
[http://dx.doi.org/10.1016/j.jep.2006.02.001] [PMID: 16540272]
[2]
Nascimento Menezes PM, Valença Pereira EC, Gomes da Cruz Silva ME, et al. Cannabis and cannabinoids on treatment of inflammation: a patent review. Rec Pat Biotechnol 2019; 13(4): 256-67.
[http://dx.doi.org/10.2174/1872208313666190618124345] [PMID: 31237222]
[3]
Li HL. An archaelogical and historical account of cannabis in China. Econ Bot 1974; 28: 437-48.
[http://dx.doi.org/10.1007/BF02862859]
[4]
Fankhauser M. Cannabis em der westlichen medizin cannabis und cannabinoide. Pharmakologie, toxikologie und therapeutisches potential. 2nd Edition. Göttingen: Hans Huber 2004; pp. 57-71.
[5]
Grotenhermen F, Müller-Vahl K. The therapeutic potential of cannabis and cannabinoids. Dtsch Arztebl Int 2012; 109(29-30): 495-501.
[http://dx.doi.org/10.3238/arztebl.2012.0495] [PMID: 23008748]
[6]
Gaoni Y, Mechoulam R. Isolamento, estrutura e síntese parcial de um constituinte ativo de haxixe. J Am Chem Soc 1964; 86: 1646-7.
[http://dx.doi.org/10.1021/ja01062a046]
[7]
Agência Nacional de Vigilância Sanitária (ANVISA). Resolução da Diretoria Colegiada RDC no. 66 Brasil: ANVISA; (RDC Nº 66). 2016.
[8]
Fischedick JT, Hazekamp A, Erkelens T, Choi YH, Verpoorte R. Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes. Phytochemistry 2010; 71(17-18): 2058-73.
[http://dx.doi.org/10.1016/j.phytochem.2010.10.001] [PMID: 21040939]
[9]
Casajuana Köguel C, López-Pelayo H, Balcells-Olivero MM, Colom J, Gual A. Psychoactive constituents of cannabis and their clinical implications: a systematic review. Adicciones 2018; 30(2): 140-51.
[PMID: 28492950]
[10]
Koren G, Boskovic R, Hard M, Maltepe C, Navioz Y, Einarson AM. PUQE (quantificação única da gravidez de emese e náuseas) sistema de pontuação para náuseas e vômitos de gravidez. Sou J Obstet Gynecol 2002; 186: S22831.
[11]
Koren G, Cohen R. Medicinal use of cannabis in children and pregnant women. Rambam Maimonides Med J 2020; 11(1): e0005.
[http://dx.doi.org/10.5041/RMMJ.10382] [PMID: 32017681]
[12]
Westfall RE, Janssen PA, Lucas P, Capler R. Pesquisa sobre o uso da cannabis medicinal entre mulheres grávidas: padrões de seu uso na gravidez e autoavaliação retroativa de sua eficácia contra ‘doença matinal’. Complement Ther Clin Pract 2006; 12: 27-33.
[http://dx.doi.org/10.1016/j.ctcp.2005.09.006] [PMID: 16401527]
[13]
Cohen R, Koren G. O uso de cannabis em hiperêmese gravidarum.Um relatório de Motherisk Israel 3º Colóquio Internacional em Hyperemesis Gravidarum; Amsterdã. Holanda 2019.
[14]
Volkow ND, Han B, Compton WM, McCance-Katz EF. Self-reported medical and nonmedical cannabis use among pregnant women in the united states. JAMA 2019; 322(2): 167-9.
[http://dx.doi.org/10.1001/jama.2019.7982] [PMID: 31211824]
[15]
Luo J, Yin JH, Wei Q. The effect of calcineurin activator, extracted from Chinese herbal medicine, on memory and immunity in mice. Pharmacol Biochem Behav 2003; 75(4): 749-54.
[http://dx.doi.org/10.1016/S0091-3057(03)00148-5] [PMID: 12957215]
[16]
Chen NY, Liu CW, Lin W, et al. Extract of fructus cannabis ameliorates learning and memory impairment induced by D-galactose in an aging rats model. Evi Compl Altern Med 2017; 4757520: 1-14.
[17]
Bergamaschi MM, Queiroz RHC, Zuardi AW, Crippa JAS. Segurança e efeitos colaterais do canabidiol, um constituinte da Cannabis sativa. Curr Drug Saf 2011; 6(4): 237-49.
[PMID: 22129319]
[18]
Dai FJ. A origem, utilização e distribuição da cannabis na China. Ensino sudoeste da China. Univ J 1989; 14: 114-9.
[19]
Brand EJ, Zhao Z. Cannabis in chinese medicine: are some traditional indications referenced in ancient literature related to cannabinoids? Front Pharmacol 2017; 8: 108.
[http://dx.doi.org/10.3389/fphar.2017.00108] [PMID: 28344554]
[20]
Pisanti S, Bifulco M. Medical Cannabis: A plurimillennial history of an evergreen. J Cell Physiol 2019; 234(6): 8342-51.
[http://dx.doi.org/10.1002/jcp.27725] [PMID: 30417354]
[21]
Fen SX. Traditional chinese medicine for treating pregnant women suffering from spleen deficiency with damp harassment. WO2018006641A1, 2018.
[22]
Shufen X. TCM drug for treating pregnant women suffering from spleen deficiency and dampness stagnation. WO2018006642A1, 2018.
[23]
Si L. Traditional chinese medicine for treating pregnant women suffering from dampness stagnancy due to spleen deficiency. CN105998825, 2016.
[24]
Si L. Traditional chinese medicine for treating spleen deficiency and damp obstruction type pregnant women. CN105963394, 2016.
[25]
Hongyan C, Sun Z, Wang X, Zhang L. Medicine for treating pregnancy with hyperthyroidism. CN104398903A, 2015.
[26]
Feng G, Lei L. Traditional Chinese medicine decoction for treating pregnancy hypertension postnatal proteinuria. CN105535847A, 2016.
[27]
Quanzhi Z, Julong Y, Bokun Z. . Edible oil suitable for pregnant and delivery women. CN107242308, 2017.
[28]
Xiaojing J, Xue M, Yue X. Traditional Chinese medicine composition for preventing postoperative complications of cesarean sectionand promoting puerperal rehabilitation. CN105477270A, 2016.
[29]
Hongjuan W. Traditional Chinese medicine preparation for treating postpartum urinary retention and preparation method thereof. CN105535292A, 2016.
[30]
Xinglian W. Traditional Chinese medicine composition for treating postpartum constipation and application thereof. CN105250634A, 2016.
[31]
Silva AP. A psique e a acupuntura. Psicol Argum 2007; 25(49): 209-11.
[http://dx.doi.org/10.7213/rpa.v25i49.20235]
[32]
Nascimento AH. Alguns aspectos da medicina tradicional chinesa e a psique humana. 2012; Available at: https://portalbiocursos.com.br/ohs/data/docs/180/112-Medicina_chinesa_e_as_essYncias_energYticas_revisYo_bibliogrYfica.pdf
[33]
Min Z. Medicine composition for treating blood stasis heating type postpartum fever and preparation method thereof. CN105561083A, 2016.
[34]
VanDolah HJ, Bauer BA, Mauck KF. Clinicians’ guide to cannabidiol and hemp oils. Mayo Clin Proc 2019; 94(9): 1840-51.
[http://dx.doi.org/10.1016/j.mayocp.2019.01.003] [PMID: 31447137]
[35]
Breit KR, Rodriguez CG, Lei A, Thomas JD. Combined vapor exposure to THC and alcohol in pregnant rats: Maternal outcomes and pharmacokinetic effects. Neurotoxicol Teratol 2020; 82: 106930.
[http://dx.doi.org/10.1016/j.ntt.2020.106930] [PMID: 33086086]
[36]
Fantasia HC. Pharmacologic implications of marijuana use during pregnancy. Nurs Womens Health 2017; 21(3): 217-23.
[http://dx.doi.org/10.1016/j.nwh.2017.04.002] [PMID: 28599743]

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