Carbon Monoxide in Renal Physiology, Pathogenesis and Treatment of Renal Disease

Title:Carbon Monoxide in Renal Physiology, Pathogenesis and Treatment of Renal Disease

Volume: 27 Issue: 41

Author(s): Qingquan Liu, Anying Cheng, Yiru Wang, Yongman Lv and Zhi Chen*

Affiliation:

• Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030,China

Keywords: Carbon monoxide, CO-releasing molecules, heme oxygenase, CO-releasing molecules, nephrotoxicity, renal ischemia/reperfusion injury, renal fibrosis.

Abstract: Carbon monoxide (CO) is one of the endogenous gaseous messengers or gasotransmitters, and is a paramount mediator in physiological and disease conditions. In this review, we focus on the functions of CO in normal and pathological renal physiology. We discuss endogenous renal CO production and signaling in the normal kidney, the characteristic of CO-releasing molecules (CORMs) modalities, and outline its regulatory functions in renal physiology. This article summarizes the mechanisms as well as the effect of CO in the evolving field of renal diseases. We predict numerous innovative CO applications forevolvingcutting-edge scholarly work in the future.

Cite this article as:

Liu Qingquan , Cheng Anying, Wang Yiru , Lv Yongman and Chen Zhi *, Carbon Monoxide in Renal Physiology, Pathogenesis and Treatment of Renal Disease, Current Pharmaceutical Design 2021; 27 (41) . https://dx.doi.org/10.2174/1381612827666210706161207