Benefits of L-Arginine on Cardiovascular System

Title:Benefits of L-Arginine on Cardiovascular System

Volume: 16 Issue: 2

Author(s): Emina Sudar-Milovanovic, Milan Obradovic, Aleksandra Jovanovic, Bozidarka Zaric, Sonja Zafirovic, Anastasija Panic, Djordje Radak and Esma R. Isenovic

Affiliation:

Keywords: Amino acid, Arginase, cardiovascular system, cardiovascular disorders, L-Arg, NO, NOS.

Abstract: The amino acid, L-Arginine (L-Arg) plays an important role in the cardiovascular system. Data from the literature show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammalian cells by L-Arg with the activity of NO synthase (NOS). In states of hypertension, diabetes, hypercholesterolemia and vascular inflammation a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations of blood vessels. Experimental results obtained on animals, as well as clinical studies show that L-Arg has an effect on thrombocytes, on the process of coagulation and on the fibrolytic system. This mini review represents a summary of the latest scientific animal and human studies related to L-Arg and its mechanisms of actions with a focus on the role of L-Arg via NO pathway in cardiovascular disorders. Moreover, here we present data from recent animal and clinical studies suggesting that L-Arg could be one of the possible therapeutic molecules for improving the treatment of different cardiovascular disorders.

Cite this article as:

Sudar-Milovanovic Emina, Obradovic Milan, Jovanovic Aleksandra, Zaric Bozidarka, Zafirovic Sonja, Panic Anastasija, Radak Djordje and Isenovic R. Esma, Benefits of L-Arginine on Cardiovascular System, Mini-Reviews in Medicinal Chemistry 2016; 16 (2) . https://dx.doi.org/10.2174/1389557515666151016125826