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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Mini-Review Article

The Application of Peptides in Glioma: A Novel Tool for Therapy

Author(s): Li Li, Jianhong Chen*, Yue Ming, Bin Li, Ruoqiu Fu, Dongyu Duan, Ziwei Li, Rui Ni, Xianfeng Wang, Yueling Zhou and Lin Zhang

Volume 23, Issue 5, 2022

Published on: 28 June, 2021

Page: [620 - 633] Pages: 14

DOI: 10.2174/1389201022666210628114042

Price: $65

Abstract

Background: Glioma is the most aggressive and lethal tumor of the central nervous system. Due to the cellular heterogeneity, the invasiveness, and blood-brain barrier (BBB), current therapeutic approaches, such as chemotherapy and radiotherapy, are poorly to obtain great antitumor efficacy. However, peptides, a novel type of therapeutic agent, displayed excellent ability in the tumor, which becomes a new molecule for glioma treatment.

Methods: We review the current knowledge on peptides for the treatment of glioma through a PubMed-based literature search.

Results: In the treatment of glioma, peptides can be used as (i) decoration on the surface of the delivery system, facilitating the distribution and accumulation of the anti-tumor drug in target site; (ii) anti-tumor active molecules, inhibiting the growth of glioma and reducing solid tumor volume; (iii) immune-stimulating factor, and it activating immune cells in the tumor microenvironment or recruiting immune cells to the tumor for breaking out the immunosuppression by glioma cells.

Conclusion: The application of peptides has revolutionized the treatment of glioma, which based on targeting, penetrating, anti-tumor activities and immunostimulatory. Moreover, better outcomes have been discovered in combining different kinds of peptides rather than a single one. Until now, more and more preclinical studies have been developed with multifarious peptides, which shows promising results in vitro or vivo with the model of glioma.

Keywords: Glioma, blood-brain barrier, peptide-based targeting therapy, cell penetrating peptide, anti-tumor activity, peptide vaccines.

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