Wound Healing Properties of Exosomes — A Review and Modelling
of Combinatorial Analysis Strategies

Fong    Fong    Liew; Boon    Cheng    Chew; Der    Jiun    Ooi
doi:10.2174/1566524021666210405131238
Abstract

Wound healing is an elaborated process, well-regulated via cell migration and proliferation. Although the physiological basics of wound healing have been thoroughly investigated and reported, much remains to be studied. Particularly, various studies have demonstrated the immunomodulatory roles of exosomes derived from plant cells, mammalian cells, and mesenchymal stem cells (MSCs) in the healing and repairing system. The paracrine and therapeutic effects of exosomes are mainly associated with the broad exosomal cargo content comprising growth factors, cytokines, enzymes, nucleic acids, proteins, and lipid signaling molecules. Nevertheless, the functional or mechanism pathway of exosomes with reference to overall exosomal cargo remains undetermined. To date, combinatorial analysis strategies employing Database for Annotation, Visualization, and Integrated Discovery (DAVID), STRING tools, Gene Ontology (GO), Kyoto Encyclopedia of Genes, Genomes (KEGG) pathway enrichment analysis, as well as Ingenuity Pathway Analysis (IPA) have been applied in elucidating network interaction and functional pathway of exosomes. In this review paper, the application of combinatorial analysis strategies is demonstrated to better understand the therapeutic potentials of exosomes in the wound healing process. In conclusion, functional modulation of exosomal cargo for specific biological treatment is achievable, and modelling of combinatorial analysis strategies will hopefully bridge the research gap and provide a paradigm shift to regenerative processes.
Keywords: Exosome, healing, combinatorial analysis, STRING tools, gene ontologY, KEGG pathway, DAVID and ingenuity pathway analysis
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DOI https://dx.doi.org/10.2174/1566524021666210405131238	Print ISSN 1566-5240
Publisher Name Bentham Science Publisher	Online ISSN 1875-5666
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