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Review Article

外泌体的伤口愈合特性— 组合分析策略的回顾与建模

卷 22, 期 2, 2022

发表于: 05 April, 2021

页: [165 - 191] 页: 27

弟呕挨: 10.2174/1566524021666210405131238

价格: $65

摘要

伤口愈合是一个精心设计的过程，通过细胞迁移和增殖得到很好的调节。虽然伤口愈合的生理基础已经过彻底调查和报道，但仍有许多研究有待研究。特别是，各种研究已经证明了来自植物细胞，哺乳动物细胞和间充质干细胞（MSCs）的外泌体在愈合和修复系统中的免疫调节作用。外泌体的旁分泌和治疗作用主要与广泛的外泌体货物含量有关，包括生长因子，细胞因子，酶，核酸，蛋白质和脂质信号分子。然而，外泌体的功能或机制途径与整体外泌体货物相关性仍未确定。迄今为止，采用注释，可视化和集成发现数据库（DAVID），STRING工具，基因本体（GO），京都基因百科全书，基因组（KEGG）通路富集分析以及独创性通路分析（IPA）的组合分析策略已应用于阐明外泌体的网络相互作用和功能通路。本文展示了组合分析策略的应用，以更好地理解外泌体在伤口愈合过程中的治疗潜力。总之，外泌体货物的功能调节用于特定的生物处理是可以实现的，组合分析策略的建模有望弥合研究差距，并为再生过程提供范式转变。

关键词: 外泌体，愈合，组合分析，STRING工具，基因本体学，KEGG途径，DAVID和独创性途径分析。

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