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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Antimycobacterial Assessment and Microwave-assisted Synthesis of 2-aryl- 3-(4-methylphenylamino)thiazolidin-4-one Derivatives

Author(s): Saad Alghamdi, Mehnaz Kamal and Mohammad Asif*

Volume 19, Issue 3, 2022

Published on: 02 March, 2021

Page: [250 - 255] Pages: 6

DOI: 10.2174/1570178618666210302160625

Price: $65

Abstract

This article reports the microwave-assisted synthesis, characterization, and evaluation of some-4-one derivatives (2a-2h) for their in-vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate Alamar blue assay (MABA) method. All these final compounds (2a-2h) were synthesized from Schiff’s bases, 1-arylidene-2-(4-methylphenyl)hydrazines (1a-1h), and thioglycolic acid by using zinc chloride as a catalyst. Compounds (1a-1h) were synthesized from the reaction of 4-methylhydrazine and appropriate aromatic aldehydes by Schiff’s reaction. Among the target compounds, 2-(4-ethoxyphenyl)-3-(4-methylarylamino)thiazolidin-4-one (2f) and 2-(4-ethylphenyl)-3-(4-methylarylamino)thiazolidin-4-one (2g) were promising with a minimum inhibitory concentration (MIC) of 12.5 μg/mL against M. tuberculosisH37Rv. Based on the preliminary results, compounds 2f and 2g were considered lead compounds for the advanced design and development of antimycobacterial agents.

Keywords: Antimycobacterial, heterocyclic, microwave-assisted synthesis, tuberculosis, 4-thiazolidinone.

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