Abstract
Aortic aneurism development is dependent on internal and external etiological factors that define the width of the therapeutic window available for the treatment of patients with such diagnosis. In this review, we provide a detailed overview of the most prominent of these factors. In particular, we discuss the input of elevated blood pressure to the remodeling of the aortic wall, describe the mechanisms of inflammatory remodeling of the aorta, and evaluate the cross-interaction of blood pressure, inflammation and immunity during the pathology development. Better understanding of this interaction will allow broadening the therapeutic options available for patients with aortic aneurism or preventive strategies for patients with known risk factors. To date, modulation of the immune signaling appears to be a promising point of the therapeutic intervention for the treatment of such patients. In this article, we also discuss the search for new diagnostic markers predicting changes in the width of the therapeutic window for the management of patients with aortic aneurysm.
Keywords: Aortic aneurysm, inflammation, therapeutic window, etiological factors, blood pressure, monocytes and macrophages, danger signals, neutrophils and mast cells.
Current Pharmaceutical Design
Title:Thoracic Aortic Aneurysm: Blood Pressure and Inflammation as Key Factors in the Development of Aneurysm Dissection
Volume: 27 Issue: 28
Author(s): Anton Postnov*, Andrey Suslov, Igor Sobenin, Ivan Chairkin, Vasily Sukhorukov, Mariam Bagheri Ekta, Victoria Khotina, Maxim Afanasiev, Peter Chumachenko and Alexander Orekhov
Affiliation:
- Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Research Institute of Human Morphology, Moscow,Russian Federation
Keywords: Aortic aneurysm, inflammation, therapeutic window, etiological factors, blood pressure, monocytes and macrophages, danger signals, neutrophils and mast cells.
Abstract: Aortic aneurism development is dependent on internal and external etiological factors that define the width of the therapeutic window available for the treatment of patients with such diagnosis. In this review, we provide a detailed overview of the most prominent of these factors. In particular, we discuss the input of elevated blood pressure to the remodeling of the aortic wall, describe the mechanisms of inflammatory remodeling of the aorta, and evaluate the cross-interaction of blood pressure, inflammation and immunity during the pathology development. Better understanding of this interaction will allow broadening the therapeutic options available for patients with aortic aneurism or preventive strategies for patients with known risk factors. To date, modulation of the immune signaling appears to be a promising point of the therapeutic intervention for the treatment of such patients. In this article, we also discuss the search for new diagnostic markers predicting changes in the width of the therapeutic window for the management of patients with aortic aneurysm.
Export Options
About this article
Cite this article as:
Postnov Anton *, Suslov Andrey, Sobenin Igor , Chairkin Ivan , Sukhorukov Vasily , Ekta Bagheri Mariam, Khotina Victoria , Afanasiev Maxim , Chumachenko Peter and Orekhov Alexander, Thoracic Aortic Aneurysm: Blood Pressure and Inflammation as Key Factors in the Development of Aneurysm Dissection, Current Pharmaceutical Design 2021; 27 (28) . https://dx.doi.org/10.2174/1381612827666210210142200
DOI https://dx.doi.org/10.2174/1381612827666210210142200 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Structure Based Virtual Screening for the Identification of Potential Inhibitors for Penicillin Binding Protein 2B of the Resistant 5204 Strain of <i>Streptococcus pneumoniae</i>
Current Bioinformatics Endophthalmitis
Anti-Infective Agents in Medicinal Chemistry The Pathophysiology of Sleep Apnoea: What We have Learned from Animal Models of Chronic Intermittent Hypoxia
Current Respiratory Medicine Reviews Anionic Antimicrobial Peptides from Eukaryotic Organisms and their Mechanisms of Action
Current Chemical Biology Anti-MRSA Cephems: An Update
Current Medicinal Chemistry - Anti-Infective Agents Platelet-Derived Chemokines in Atherogenesis: What’s New?
Current Vascular Pharmacology Acute Decompensated Heart Failure Update
Current Cardiology Reviews Inhibition of Quorum Sensing in Staphylococcus spp.
Current Pharmaceutical Design Transcatheter Aortic Valve Implantation Infective Endocarditis: Current Data and Implications on Prophylaxis and Management
Current Pharmaceutical Design Contrast Enhanced Sonography for Diagnosis of (Peri-) Splenic Pathology
Current Medical Imaging Additive Effect of MCP in Combination with Cefotaxime Against Staphylococcus aureus
Medicinal Chemistry Staphylococcus aureus: Current State of Prevalence, Impact, and Vaccine Development
Current Pharmaceutical Design Targeting RGD Recognizing Integrins: Drug Development, Biomaterial Research, Tumor Imaging and Targeting
Current Pharmaceutical Design Treatment Options for Persistent Coagulase Negative Staphylococcal Bacteremia in Neonates
Current Pediatric Reviews Current Status of Molecular Imaging in Infections
Current Pharmaceutical Design Uveitis in Rheumatic Diseases
Current Rheumatology Reviews In Vitro Synergistic Action of Certain Combinations of Gentamicin and Essential Oils
Current Medicinal Chemistry New Synthetic Antibiotics for the Treatment of Enterococcus and Campylobacter Infection
Current Topics in Medicinal Chemistry Clinical Presentations and Diagnosis of Brucellosis
Recent Patents on Anti-Infective Drug Discovery The Role of the Coagulase-negative Staphylococci (CoNS) in Infective Endocarditis; A Narrative Review from 2000 to 2020
Current Pharmaceutical Biotechnology